Asha Therapeutics

Discussion in 'ME/CFS research news' started by Braganca, Jan 4, 2024.

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  1. Braganca

    Braganca Senior Member (Voting Rights)

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    https://www.ashatherapeutics.com/ourscience

    Post-viral Illness (Long COVID & ME/CFS)
    Mitochondrial Fragmentation is the Commonality

    Post-viral illnesses are a set of chronic pathologies with multiple symptomatic profiles including ME/CFS and Long COVID.

    Similar to approaches for AD and PD, ASHA-091 intervention in preclinical models of post-viral illness is proving efficacious. Interestingly, ASHA-091 was designed specifically as the first targeted therapy for ME/CFS and post-viral illness and has since proven to have a host of other therapeutic indications including AD and PD as highlighted above.

    https://www.ashatherapeutics.com/post/me-cfs

    https://twitter.com/user/status/1667632490213670915


    https://www.heckmannlab.com/pi-bio
     
  2. Braganca

    Braganca Senior Member (Voting Rights)

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  3. Mij

    Mij Senior Member (Voting Rights)

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  4. JemPD

    JemPD Senior Member (Voting Rights)

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    oh :banghead:

    You cannot possibly even have a 'mouse model' of ME. PEM is not 'healthy mouse/human having done much more exercise than they're used to'. You cant possibly give a healthy organism 'enough' exhaustion to trigger PEM. PEM is not PEF.

    :banghead::banghead::banghead::banghead::banghead::banghead::banghead::banghead::banghead::banghead::banghead:
     
    Louie41, Mij, EndME and 5 others like this.
  5. Braganca

    Braganca Senior Member (Voting Rights)

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    Yeah the mouse model is unlikely. They did inject the mouse to “induce mitochondrial fragmentation” with two different substances.

    Is “DRP1-mediated mitochondrial fragmentation” something anyone has found in ME studies?

    Seems like a stretch but happy to see ME as a potential indication, even at a v early, pre-clinical stage.
     
    Jaybee00, Louie41, DokaGirl and 2 others like this.
  6. Wonko

    Wonko Senior Member (Voting Rights)

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    It'll all be fine.

    All they need is a drug to turn people into mice, and one to turn them back to people, maybe even the same people.

    Then they can turn someone into a mouse, use the mouse model derived treatment to cure their ME, and then turn them back into a person.

    Simple really.
     
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  7. Mij

    Mij Senior Member (Voting Rights)

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  8. Wonko

    Wonko Senior Member (Voting Rights)

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    I foresee such vehicles experiencing similar issues to those with the Sinclair C5 - absolutely useless for travel on motorways.
     
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