Anti-convulsants - Pregabalin and Gabapentin

Arfmeister said:
As an anecdote: I always have wondered why taking a high dosage of Pregabalin 1x/week (at night) is able to lower all my ME-symptoms immediately within 1 hour - for about 12-15 hours.
- this includes PEM symptoms flu-like symptoms, brain fog, fatigue, orthostatic intolerance, insomnia, etc
(I am very severe so It’s nothing earth-shaking, but still makes a big difference)
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rapidboson said:
I have seen the same effect of pregabalin or gabapentin. I am wondering though if it's just a higher dose making you feel good/high and masking symptoms or whether it's actually temporarily "healing" the symptoms.
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Interesting because Gabapentin 700 late afternoon & 1200 at night (for something else), makes me feel 'better than i have done all day' in terms of flu-like sensetions - ie bodily. But the fog, the drunkeness effect is terrible, very intense. & it also makes me think i can do things i cant actually do. Pacing is much harder to do now i'm on it. I do all kinds of things during the evening/night that i wonder how i could have been so stupid the next day!
 
Yes thanks that makes sense but I can’t take it at that time unfortunately because the pain relief takes 3hrs to kick in so I have to take it 9pm,

like I said it makes me feel drunk making pacing or indeed any sensible decision/self discipline, very difficult and given just reading/ listening to a story is often too much exertion, it’s pretty challenging when both foggy & stoned!

it’s does impact the pain though (not ME/CFS related) without which sleep would be impossible
 


I have been taking Pregabalin for almost 3 years (saved my life). I thought about why it might work (GABA/Glutamate). To test it, I started Lamotrigine, works wonders. And now I see this preprint by Wirth/Scheibenbogen. @C_Scheibenbogen: for
me it works, subgroup?
 
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