An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

[Jaybee00]

An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals


https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216385

In use since 1696! How about that? Maybe test in the nano-needle? (different mechanism than SS-31)

 

[roller*]

... but unexpectedly decreases mitochondrial reactive oxygen species (ROS/H2O2) production by acting as a specific inhibitor of ROS production at the IQ site of complex I of the mitochondrial respiratory chain.

These applications include but are not limited to aging, Parkinson’s and Alzheimer's diseases, cardiac atrial fibrillation, and ischemia-reperfusion injury.

OP2113
CAS 532-11-6
5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione,
Anethole trithione | C10H8OS3

Anethole trithione is an oltipraz analog that is clinically used to treat xerostomia ( dry mouth).

Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in the U.S. National Cancer Institute's Dictionary of Cancer Terms as being studied in the treatment of cancer.[1] Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative.

Brand names
Felviten
Halpen
Hepasulfol - Franco-Indian Pharmaceuticals
Heporal
Mucinol - Sanofi-Aventis
Sialor - Paladin Laboratories; Pharmascience; Solvay; Zuoz Pharma
Sonicur - Solvay
Sulfarlem - Solvay; Aguettant; Edward Keller; Sanofi-Aventis
Sulfarlem S - EG Labo
Tiopropen
Tiotrifar
https://en.wikipedia.org/wiki/Anethole_trithione

 

[Wonko]

So I should get over my aversion to Pernod?

 

[NelliePledge]

So I should get over my aversion to Pernod?

Vile stuff

ETA i eat loads of fennel though that’s yummy

 

[Hip]

I've a bottle of pure anethole, which I took internally at 12 drops daily for 5 months. I did not notice much, though it may have improved my IBS-D symptoms a little.

Anethole though is not quite the same molecule as anethole trithione, so I am not sure if anethole has these antioxidant effects in mitochondria.



Anethole is the primary ingredient of:

Fennel essential oil
Anise essential oil
Star anise essential oil

Anethole is found in the alcoholic drinks sambuca, ouzo, pastis and Pernod. (I am particularly fond of sambuca).

 

[Jaybee00]

Yeah anethole is different from anethole trithione— the former doesn’t have the three sulfur molecules.

 

[roller*]

anyone found how this med was called in 1696 or for what it was used ?

 

[Jaybee00]

here is a short summary of this research.

https://www.fightaging.org/archives/2019/05/anethole-trithione-is-a-mitochondrial-ros-blocker/

 

[roller*]

SS31 = elamipretide which naviaux seems to suggests
MitoQ = supplement similar to coQ10
SkQ1 = cardiolipin peroxidation inhibitor, 95% pwmecfs have auto-antibodies
Sulfarlem = 60 pills 1.31 Euro, France and Switzerland

Mitochondria, the power plants of the cell, generate reactive oxygen species (ROS) as a side effect of the energetic operations

excessive ROS generation can be harmful.

A number of mitochondrially targeted antioxidant compounds have been developed over the past fifteen years, and shown to produce at least some these benefits: MitoQ, SkQ1, SS31, and so forth.

Regardless, a small class of mitochondrial ROS blocker compounds does exist, and here researchers show that the approved drug anethole trithione, also known as sulfarlem, and in this paper, confusingly, by the designation OP2113, is also a mitochondrial ROS blocker. It can achieve this goal without greatly altering mitochondrial function. It remains to be seen as to whether this compound can do as well as mitochondrially targeted antioxidants, should it or an improved version be further developed for this clinical use.