An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals


https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216385

In use since 1696! How about that? Maybe test in the nano-needle? (different mechanism than SS-31)

 

OP2113
CAS 532-11-6
5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione,
Anethole trithione | C10H8OS3

 

So I should get over my aversion to Pernod?

 

I've a bottle of pure anethole, which I took internally at 12 drops daily for 5 months. I did not notice much, though it may have improved my IBS-D symptoms a little.

Anethole though is not quite the same molecule as anethole trithione, so I am not sure if anethole has these antioxidant effects in mitochondria.



Anethole is the primary ingredient of:

Fennel essential oil
Anise essential oil
Star anise essential oil

Anethole is found in the alcoholic drinks sambuca, ouzo, pastis and Pernod. (I am particularly fond of sambuca).

 

Yeah anethole is different from anethole trithione— the former doesn’t have the three sulfur molecules.

 

anyone found how this med was called in 1696 or for what it was used ?

 

here is a short summary of this research.

https://www.fightaging.org/archives/2019/05/anethole-trithione-is-a-mitochondrial-ros-blocker/

 

SS31 = elamipretide which naviaux seems to suggests
MitoQ = supplement similar to coQ10
SkQ1 = cardiolipin peroxidation inhibitor, 95% pwmecfs have auto-antibodies
Sulfarlem = 60 pills 1.31 Euro, France and Switzerland