Amyloid-forming potential of Betacoronavirus including SARS-CoV-2
Hazem Haddad, Walid Al-Zyoud
Abstract
Prions are considered as sub-viral protein particles that have exceptional ability for multiple structural or functional conformational changes, leading to amyloid or prion forming or priogenicity, that any might affect the regulation of viral infections.
The aim of this study is to utilize two computational platforms to predict the ability of the priogenicity of Betacoronavirus including SARS-CoV-2 clades. The abovementioned computational platforms included two algorithms; the Prion Aggregation Prediction Algorithm (PAPA) and the Supervised Machine Learning Algorithm Called Prion RANKing and Classification (pRANK) because of their high classifier performance proteome wide when compared with other algorithms, such as PLAAC-LLR and prionW.
The findings of this study imply the high potential of some Betacorona viruses, including the Wild type of SARS-CoV-2 and some variants, such as Gamma and Delta, to develop prion-like sequence which can act as a regulator for viral infections.
Link | PDF (Heliyon) [Open Access]
Hazem Haddad, Walid Al-Zyoud
Abstract
Prions are considered as sub-viral protein particles that have exceptional ability for multiple structural or functional conformational changes, leading to amyloid or prion forming or priogenicity, that any might affect the regulation of viral infections.
The aim of this study is to utilize two computational platforms to predict the ability of the priogenicity of Betacoronavirus including SARS-CoV-2 clades. The abovementioned computational platforms included two algorithms; the Prion Aggregation Prediction Algorithm (PAPA) and the Supervised Machine Learning Algorithm Called Prion RANKing and Classification (pRANK) because of their high classifier performance proteome wide when compared with other algorithms, such as PLAAC-LLR and prionW.
The findings of this study imply the high potential of some Betacorona viruses, including the Wild type of SARS-CoV-2 and some variants, such as Gamma and Delta, to develop prion-like sequence which can act as a regulator for viral infections.
Link | PDF (Heliyon) [Open Access]
