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Altered central and peripheral hemodynamics during rhythmic handgrip exercise in young adults with SARS-CoV-2, 2021, Stute et al

Discussion in 'Epidemics (including Covid-19, not Long Covid)' started by Andy, Jul 28, 2021.

  1. Andy

    Andy Committee Member

    Hampshire, UK

    New Findings

    • What is the central question of this study?
    • This study sought to investigate whether central and peripheral hemodynamics during handgrip exercise were different in young adults 3–4 weeks following infection with of SARS-CoV-2 compared with young healthy adults.
    • What is the main finding and its importance?
    • The main findings are that exercising heart rate was higher while brachial artery blood flow and vascular conductance were lower in the SARS-CoV-2 compared with the control group. These findings provide evidence for peripheral impairments to exercise among adults with SARS-CoV-2, which may contribute to exercise limitations.

    The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can have a profound impact on vascular function. While exercise intolerance may accompany a variety of symptoms associated with SARS-CoV-2 infection, the impact of SARS-CoV-2 on exercising blood flow (BF) remains unclear.

    : Central (photoplethysmography) and peripheral (Doppler ultrasound) hemodynamics were determined at rest and during rhythmic handgrip exercise at 30% and 45% of maximal voluntary contraction (MVC) in young adults with mild symptoms 25 days after testing positive for SARS-CoV-2 (SARS-CoV-2: n = 8M/5F; Age: 21±2yrs; Height: 176±11cm; Mass: 71±11kg) and were cross-sectionally compared with control subjects (Control: n = 8M/5F; Age: 27±6yrs; Height: 178±8cm; Mass: 80±25kg).

    : Systolic blood pressure, end systolic arterial pressure, and rate pressure product were higher in the SARS-CoV-2 group during exercise at 45%MVC compared with Controls. Brachial artery BF was lower in the SARS-CoV-2 group at both 30%MVC (Control: 384.8±93.3ml·min–1; SARS-CoV-2: 307.8±105.0ml·min–1; p = 0.041) and 45%MVC (Control: 507.4±109.9ml·min–1; SARS-CoV-2: 386.3±132.5ml·min–1; p = 0.002). Brachial artery vascular conductance was lower at both 30%MVC (Control: 3.93±1.07ml·min–1·mmHg–1; SARS-CoV-2: 3.11±0.98ml·min–1·mmHg–1; p = 0.022) and 45%MVC (Control: 4.74±1.02ml·min–1·mmHg–1; SARS-CoV-2: 3.46±1.10ml·min–1·mmHg–1; p<0.001) in the SARS-CoV-2 group compared to Control group. The shear-induced dilation of the brachial artery increased similarly across exercise intensities in the two groups, suggesting the decrease in exercising blood flow may be due to microvascular impairments.

    : Brachial artery BF is attenuated during handgrip exercise in young adults recently diagnosed with mild SARS-CoV-2, which may contribute to diminished exercise capacity among those recovering from SARS-CoV-2 like that seen in severe cases.

    Open access, https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP089820
    Milo, Hutan, Wyva and 10 others like this.
  2. alktipping

    alktipping Senior Member (Voting Rights)

    : Brachial artery BF is attenuated and did they find a reason for this attenuation and presumably reduced blood flow ?
    Hutan and Peter Trewhitt like this.
  3. Hutan

    Hutan Moderator Staff Member

    Aotearoa New Zealand
    It's sounding like the artery is doing what it should, dilating to allow more blood through in response to exercise. In the post-Covid cohort, heart rate increased, so the heart was trying to pump the blood though. The authors seem to think there is a blockage down stream - so the capillaries or the venules aren't working right.

    It's notable that a large number of the post-Covid cohort had mild fatigue.

    It would be nice to see the same study done in people with overt Long Covid, and with ME/CFS.
    alktipping, Trish, oldtimer and 2 others like this.
  4. Milo

    Milo Senior Member (Voting Rights)

    Comparison studies are essential. At this point in the game, the 2 diseases should not work in silos. But then it seems to me that they need to define ‘Long-COVID’, what symptoms are typical and what symptom is actually organ damage or other pathologic process.
    alktipping, Snowdrop, Wyva and 3 others like this.

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