Alpha-7 nicotinic acetylcholine receptor literature

Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia Jason R Tregellas, PhD, Korey P Wylie, MD
https://academic.oup.com/ntr/article/21/3/349/5078145

The role of a recently discovered Alpha-7 nicotinic acetylcholine receptor on amyloid-beta pathology in Alzheimer's disease
https://www.alzheimersanddementia.com/article/S1552-5260(17)33525-2/fulltext

The role of alpha-7 nicotinic receptors in food intake behaviors
Kristina L. McFadden1, Marc-Andre Cornier2 and Jason R. Tregellas1,3*
https://www.frontiersin.org/articles/10.3389/fpsyg.2014.00553/full

Alpha 7 nicotinic acetylcholine receptor and its effects on Alzheimer's disease
https://www.sciencedirect.com/science/article/pii/S0143417918301446

Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895566/

Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model
https://www.nature.com/articles/s41598-017-02092-6

 

Activation of a7 Nicotinic Acetylcholine Receptors Prevents Monosodium Iodoacetate-Induced Osteoarthritis in Rats
Liu Y.b · Wu D.c · Song F.a · Zhu C.a · Hui Y.a · Zhu Q.a · Wu J.d · Fan W.a · Hu J.a
https://www.karger.com/Article/Fulltext/369724

The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism
https://www.ijbs.com/v13p0046.htm

Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292018/

Nicotinic (α7) Receptors
Alpha 7 (α7) is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. The α7 nAChR is prominent in the hippocampus, found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.
https://www.tocris.com/pharmacology/nicotinic-alpha7-receptors

 

https://www.s4me.info/threads/wesse...holine-receptor-literature.12561/#post-221439

The availability of the α7 nicotinic acetylcholine receptor in recent-onset psychosis: a study using 18F-ASEM PET
Limited postmortem evidence suggests a diminished availability of the α7 nicotinic acetylcholine receptor (α7-nAChR) in hippocampus in psychosis

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
http://pharmrev.aspetjournals.org/content/67/4/1025


Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0967-6

Ethanol-Induced Motor Impairment Mediated by Inhibition of α7 Nicotinic Receptors
https://www.jneurosci.org/content/36/29/7768

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894934/

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders

Notably, the anti-inflammatory response to α7 nAChR stimulation also occurs in the brain. Thus, activation of α7 nAChRs is known to alter the phenotype of both macrophages and microglia from an M1-like to an M2-like phenotype [11, 19, 82, 83]. Consequently, any dysfunction in the α7 nAChR and its signaling processes could tip the balance towards more inflammation.


Although not yet reported, a similar co-agonist effect may occur at α7 receptors expressed by immune cells. If true, this would imply that low doses of a α7 nAChR agonist would be sufficient to enhance the anti-inflammatory response to the endogenous agonists (choline and/or acetylcholine).

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687317/

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials

The alpha-7 nicotinic acetylcholine receptor (α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca2+-permeable ion channel implicated in cognition and neuropsychiatric disorders.