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Alpay, Baykan, et al. Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial. (2010)

Discussion in 'Other health news and research' started by WillowJ, Dec 15, 2018.

  1. WillowJ

    WillowJ Senior Member (Voting Rights)


    Introduction: It is well-known that specific foods trigger migraine attacks in some patients. We aimed to investigate the effect of diet restriction, based on IgG antibodies against food antigens on the course of migraine attacks in this randomised, double blind, cross-over, headache-diary based trial on 30 patients diagnosed with migraine without aura.

    Methods: Following a 6-week baseline, IgG antibodies against 266 food antigens were detected by ELISA. Then, the patients were randomised to a 6-week diet either excluding or including specific foods with raised IgG antibodies, individually. Following a 2-week diet-free interval after the first diet period, the same patients were given the opposite 6-week diet (provocation diet following elimination diet or vice versa).

    Patients and their physicians were blinded to IgG test results and the type of diet (provocation or elimination). Primary parameters were number of headache days and migraine attack count. Of 30 patients, 28 were female and 2 were male, aged 19–52 years (mean, 35 ± 10 years).

    Results: The average count of reactions with abnormally high titre was 24 ± 11 against 266 foods. Compared to baseline, there was a statistically significant reduction in the number of headache days (from 10.5 ± 4.4 to 7.5 ± 3.7; P < 0.001) and number of migraine attacks (from 9.0 ± 4.4 to 6.2 ± 3.8; P < 0.001) in the elimination diet period.

    Conclusion: This is the first randomised, cross-over study in migraineurs, showing that diet restriction based on IgG antibodies is an effective strategy in reducing the frequency of migraine attacks.

    Keywords: migraine, food, diet, IgG, trigger
    MarcNotMark, Sasha, Amw66 and 3 others like this.
  2. WillowJ

    WillowJ Senior Member (Voting Rights)

    "There is growing evidence that inflammation plays an important role in the pathogenesis of migraine (2). The calcitonin gene-related peptide (CGRP), and nitric oxide (NO) may participate in immune and inflammatory responses.

    "Some patients report that certain foods only trigger migraine in conjunction with stress or extended physical exercise.

    "Both conditions, recognised as triggers of migraine, cause the release of pro-inflammatory cytokines. In these cases, inflammation caused by food could create the pro-inflammatory milieu necessary for the induction of migraine by other triggers.

    "If we focus on inflammation induced by food, a specific marker is needed. All IgG subclasses, except IgG4 lead to an inflammatory response when in contact with the respective antigen. Determination of specific IgG to a large number of foods is an ideal tool to detect individually suspected food and enables a modification of nutritional habits in order to prevent chronic inflammation and onset of migraine in sensitised patients.

    "Susceptibility to other triggers such as histamine, caused by impaired detoxification by low activity of di-amino-oxidase, may play an additional role and could be considered in the proposed diet."
    Skycloud, Peter Trewhitt and Trish like this.
  3. unicorn7

    unicorn7 Senior Member (Voting Rights)

    Oh interesting! I have had this test as well and have followed the diet for three years now.
    Skycloud likes this.

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