Addiction drug shows promise lifting long COVID brain fog, fatigue

The drug has been used with some success to treat a similar complex, post-infectious syndrome marked by cognitive deficits and overwhelming fatigue called myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Drawing on its use in ME/CFS and a handful of long COVID pilot studies, there are now at least four clinical trials planned to test naltrexone in hundreds of patients with long COVID, according to a Reuters review of Clinicaltrials.gov and interviews with 12 ME/CFS and long COVID researchers.

https://www.reuters.com/business/he...ting-long-covid-brain-fog-fatigue-2022-10-18/

 

I can only see two studies on Clinicaltrials.gov that aren't withddrawn:

Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 Syndrome
Uncontrolled, unblinded. Yawn.

Low-dose Naltrexone for Post-COVID Fatigue Syndrome
Double-blinded, 80 in each arm (LDN and placebo). Phase 2 study in Canada. Looking good.

 

Given how its gone with ME/CFS patients who have tried it so far I don't imagine it will be very successful for most people.

 

I tried low-dose naltrexone (LDN) for m.e. for a month, but had
constant nausea and several episodes of prolonged severe
nausea, vomiting, delayed gastric emptying, sweating,
diarrhea, and worse IBS.

In one episode, I needed to vomit for about 7 hours but
could not. Strange regurgitating. When finally vomited,
was a large amount.

This is the first time I had gastroparesis. In 2016 (a few
years later) I was diagnosed with Gastroparesis (See file
median-other--a.org). It continues.

Thus, LDN seems to have caused gastroparesis.


Recovery from the physical stress of having to kneel due to
nausea was months or longer, possibly permanent. I am
bedridden and must be supine.


I have low level nausea most of the time.

No anti-nausea works (See file median-other--a.org) for any
type of nausea except that metoclopramide (generic Reglan)
helps severe gastroparesis.


I used a compounding pharmacy, who were given strict
instructions to use pure LDN plus acidophilus filler,
immediate release. Not crushed tablets.

However, they admitted later that they used crushed tablets.

I do not know whether the reactions were caused by the
crushed tablets or by LDN itself.


I take strong measures to prevent gastroparesis including
lying on left side for many hours, food-processed food.