A study I want someone to do

[wigglethemouse]

This comes back to the point made by Mike Murphy, the mitochondrial chap, that ME symptoms do not look like severe metabolic defects of the sort seen in heart failure or mitochondrial failure.

This study found heart issues @Jonathan Edwards
Paper : Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627316/

Results
Compared to controls, the CFS group had substantially reduced left ventricular mass (reduced by 23%), end-diastolic volume (30%), stroke volume (29%) and cardiac output (25%). Residual torsion at 150% of the end-systolic time was found to be significantly higher in the patients with CFS (5.3±1.6°) compared to the control group (1.7±0.7°, P=0.0001). End-diastolic volume index correlated negatively with both torsion-to-endocardial-strain ratio (TSR) (r= -0.65, P=0.02) and the residual torsion at 150% end-systolic time (r= -0.76, P=0.004), so decreased end-diastolic volume is associated with raised TSR and torsion persisting longer into diastole. Reduced end-diastolic volume index also correlated significantly with increased radial thickening (r= -0.65, P=0.03) and impaired diastolic function represented by the ratio of early to late ventricular filling velocity (E/A ratio, r=0.71, P=0.009) and early filling percentage (r=0.73, P=0.008).

If I understand right by referring to the text of the study, radial thickening is a thickening of the heart wall. This particular effect is also noted with people suffering Mitochondrial Complex V dysfunction (similar dysfunction perhaps to that Paul Fisher has identified).
https://ghr.nlm.nih.gov/condition/mitochondrial-complex-v-deficiency

Another common feature of mitochondrial complex V deficiency is hypertrophic cardiomyopathy. This condition is characterized by thickening (hypertrophy) of the heart (cardiac) muscle that can lead to heart failure.

Did I interpret that right?

 

[Marco]

Might not be relevant but I have a question.
I recently tried some games (Elevate and Luminosity). The task switching games were weird because I often found that I knew the correct answer (task switching working ok) but couldn’t remember how to work the controls (do you swipe from or to the direction you want? Is it the left button or the right button that says ‘yes’? Etc.). This is a rapid fire game (well, supposed to be) where I’ve successfully used the control repeatedly less than a second before but suddenly I can’t remember how it works.
Is there a name for this? Or is that just normal?

At least one study suggests PWME do much worse on tasks involving multi-tasking - perhaps that's the issue?

 

[Woolie]

@Marco, @Subtropical Island, "multitasking" tasks are pretty sensitive to all kinds of general cognitive problems, so yes, you'd expect them to be difficult for PwMEs. But while sensitive, they're not that specific, so they don't give us a lot of clues as to what the exact problem is.

What @Subtropical Island describes is interesting though. Your problem on the task doesn't sound like a "memory" problem per se, at least not in the sense in which we normally think of memory - remembering past events - because the brain regions that support that kind of memory are not needed for the kind of task you're talking about here. It could just be that the high demands of the task lead to occasional cognitive overload, which makes you feel suddenly frozen, like you can't remember what to do.