Sasha
Senior Member (Voting Rights)
Nothing specific. I am just basing it on the general systems dynamics principle that if you have a bistable situation where dynamics can either lodge in a normal feedback loop or drift off into an abnormal cycle the longer that goes on the more likely you are to recruit changes that entrench the abnormal cycle. The immune system has millions of options for shifting control loops to a slightly different position with B and T cell subpopulations changing.
Does this happen in RA and other diseases (assuming they're the sort of bistable thing you're talking about) - namely, that the longer you've had it, the harder you are to treat and the less likely you are to go into remission, especially long-term remission?
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