Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

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That's interesting. I wonder if that would mean, though, that you'd expect the level of the intolerances to be correlated, such that a person who is very intolerant to sensory stimuli would also be very intolerant to meds, and vice versa. I'm completely tolerant to sensory stimuli AFAIK but have huge problems with some meds.

I assume it would just depend which nerves/cells/bits are sensitised. There is a great deal of variation between us. So I wouldn’t expect there to need to be a clear correlation.

I didn’t think I had any medication sensitivities but then found some seem to set me off. Some seems like a more pronounced version of normal stuff people get (nausea etc) which to me is like the body saying ‘new chemical, I may be being poisoned, react’ while others are more clearly neural, like bounceback from certain sleeping meds. I can vaguely get a feel for how it all fits into the overall-responsiveness hypothesis.

 

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@Jonathan Edwards would the elispot/co-culture experiments proposed be possible on already collected blood samples, like those in the CureME biobank? Those are what Jackie was using for previous studies of T cells iirc, but I think they were using flow cytometry and I have no idea about these different methods or their requirements.