Preprint A case of post-COVID-19 [ME/CFS] characterized by post-exertional malaise and low serum acylcarnitine level , 2022, Jinushi et al

[Sly Saint]

preprint
A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level
2022 Jinushi et al

Abstract
COVID-19 afflicts patients with acute symptoms and longer-term sequelae. One of the sequelae is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), which is often difficult to diagnose, having no established tests. In this article, we synthesize information from literature reviews on patients with ME/CSF that developed after recovery from COVID-19.

https://www.authorea.com/doi/full/10.22541/au.166970885.57585536/v1

 

[InitialConditions]

ME/CSF

No.

 

[Trish]

This is a preprint by a group of gastroenterology and internal medicine doctors in Japan.
I've only skimmed it, but I'd say they have only skimmed ME research.
A few clangers:

ME/CFS causes various symptoms such as morbid fatigue, pain, and mental disorders that worsen after exertion;

In ME/CFS, any form of strenuous exercise should be avoided. In contrast, graded exercise therapy and cognitive behavioral therapy have been reported to be safe and effective (12).
12. White PD, Goldsmith KA, Johnson AL, et al. Comparison of Adaptive Pacing Therapy, Cognitive Behaviour Therapy, Graded Exercise Therapy, and Specialist Medical Care for Chronic Fatigue Syndrome (PACE): A Randomised Trial. Lancet 377:823-836, 2011 Mar 5. doi: 10.1016/S0140-6736(11)60096-2.

Despite varied opinion in these references about the precise role of l-carnitine in fatty acid oxidation, there is widespread agreement that ME/CFS is associated with changes in acylcarnitine and l-carnitine homeostasis (16)
16. Kuratsune H, Yamaguti K, Watanabe Y, et al. Acylcarnitine and Chronic Fatigue Syndrome. in: Carnitine Today. De Simone C, Famularo G Eds. RG Landes Company, Austin, 1997:195-213

 

[InitialConditions]

I'm afraid much of the research in this area from Japan and China is not worth the paper it's written on. It's strange because in some areas — such as solid-state physics — they excel.

"16. Kuratsune H, Yamaguti K, Watanabe Y, et al. Acylcarnitine and Chronic Fatigue Syndrome. in: Carnitine Today. De Simone C, Famularo G Eds. RG Landes Company, Austin, 1997:195-213"

I must get my hands on the latest issue of Carnitine Today...

 

[Sly Saint]

No.

don't shoot the messenger; I just copied and pasted the abstract

 

[InitialConditions]

don't shoot the messenger; I just copied and pasted the abstract

Yes, I realised that! This is more common than it should be. I've seen it dozens of times.

 

[Trish]

Now published

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04226-z#:~:text=Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is,with adequate rest [1].

This looks like a different paper by the same team.

New thread here:

Comparison of serum acylcarnitine levels in patients with [ME/CFS] and healthy controls: a systematic review and meta-analysis, 2023, Jinushi et al.