A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease, 2020, Cairns et al.

[cassava7]

Dana M. Cairns [1,2], Nicolas Rouleau [1,2], Rachael N. Parker [1], Katherine G. Walsh [3], Lee Gehrke [4] and David L. Kaplan [1,2]*

1. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
2. Allen Discovery Center, Tufts University, Medford, MA 02155, USA.
3. Department of Biology, Tufts University, Medford, MA 02155, USA.
4. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Science Advances 06 May 2020

Alzheimer’s disease (AD) is a neurodegenerative disorder that causes cognitive decline, memory loss, and inability to perform everyday functions. Hallmark features of AD—including generation of amyloid plaques, neurofibrillary tangles, gliosis, and inflammation in the brain—are well defined; however, the cause of the disease remains elusive. Growing evidence implicates pathogens in AD development, with herpes simplex virus type I (HSV-1) gaining increasing attention as a potential causative agent. Here, we describe a multidisciplinary approach to produce physiologically relevant human tissues to study AD using human-induced neural stem cells (hiNSCs) and HSV-1 infection in a 3D bioengineered brain model. We report a herpes-induced tissue model of AD that mimics human disease with multicellular amyloid plaque–like formations, gliosis, neuroinflammation, and decreased functionality, completely in the absence of any exogenous mediators of AD. This model will allow for future studies to identify potential downstream drug targets for treating this devastating disease.

Link: https://advances.sciencemag.org/content/6/19/eaay8828

STAT article: https://www.statnews.com/2020/05/06/researchers-show-herpes-link-to-alzheimers/