Cochrane reviews are becoming increasingly complex as methods evolve, as data sources become more diverse, and as we increasingly recognize that health outcomes are the products of many interlinked elements. Cochrane pioneered the publication of protocols before undertaking systematic reviews, partly to help ensure that the many decisions we make along the way are objective and not based on the results of the identified studies.
This year’s Methods Symposium will examine whether our protocols continue to provide the road map we need to navigate a modern Cochrane review. We will explore how much can reasonably be anticipated about the decisions we need to make. Speakers will address several aspects of pre-specification from diverse methodological perspectives, showcasing updated material in the new
Cochrane Handbook for Systematic Reviews of Interventions (Version 6). Issues for discussion include deciding what syntheses are to be performed, deciding which data to extract and analyse, and dealing with issues of complexity in interventions and study contexts. We will discuss the extent to which issues can be overcome with careful review planning, and aim to determine whether refinements are needed in our current guidance for writing protocols.