I just came upon this, and thought it was pretty funny how badly it has aged. The first two sentences are hilarious imo: the "obvious paradox" and then the "should be proof enough". He's showing off about the fact that he doesn't know how to think. Should be proof enough?! Acknowledge good intentions of researchers in CFS/ME Alastair M Santhouse, consultant in psychological medicine1 + Author Affiliations 1South London and Maudsley NHS Foundation Trust, London SE5, UK There is an obvious paradox in wanting more research into chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) but rejecting research that is not liked, with claims that it is unscientific.1 “Science” is the application of the scientific method, and the sound rebuttals by the Medical Research Council and the Lancet to allegations that the PACE trial was in some way improper should be proof enough. That the PACE trial found cognitive behavioural therapy and graded exercise therapy to be safe while moderately improving outcomes in CFS/ME would cause great satisfaction to doctors and patients in any other branch of medicine. Entry criteria to the trial were broad,2 3 4 but subgroup analysis on more narrowly defined CFS/ME gave the same results. Although such treatments do not work for everyone, undoubtedly they benefit some. It is precisely for these reasons that we have trials in which treatments and outcomes can be standardised. Of course we need research into other areas of this condition, but let us also acknowledge the good intentions of researchers and doctors involved in all aspects of this field. Notes Cite this as: BMJ 2011;343:d4550 Footnotes Competing interests: AMS is a specialist medical care doctor, PACE trial, and member of the guideline development group of the National Institute for Health and Clinical Excellence (NICE) CFS/ME guidelines. References 1 Hawkes N. Dangers of research into chronic fatigue syndrome. BMJ2011;342:d3780. (22 June.) [FREE Full text] 2 Sharpe MC, Archard LC, Banatvala JE, Borysiewicz LK, Clare AW, David A, et al. A report—chronic fatigue syndrome: guidelines for research. J R Soc Med1991;84:118-21. [Medline] [Web of Science] 3 Reeves WC, Lloyd A, Vernon SD, Klimas N, Jason LA, Bleijenberg G, et al; International Chronic Fatigue Syndrome Study Group. Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res2003;3:25. [CrossRef] [Medline] 4 National Task Force. London criteria. Report on chronic fatigue syndrome (CFS), post viral fatigue syndrome (PVFS) and myalgic encephalomyelitis (ME). 1994.