11 clinical trials that will shape medicine in 2023, 2022, Carrie Arnold

[Mij]

1. A diabetes drug for Parkinson's disease

2. ADC for ovarian cancer

3. CRISPR-Cas9 for muscular dystrophy

4. Cervical cancer screening in the vaccinated

5. The Mediterranean diet for weight loss

6. Safe treatment for sleeping sickness

7. Circulating tumor cells

8. Lecanemab for Alzheimer's disease

9. COVID-19 vaccination and HIV

10. Gene editing for sickle-cell disease

11. Reducing harm for prostate cancer screening


https://www.nature.com/articles/s41591-022-02132-3

 

[Jaybee00]

Thanks for posting this. I had no idea about using exenatide for Parkinson’s—Some speculation on mechanism here

https://bmjopen.bmj.com/content/bmjopen/11/5/e047993.full.pdf

 

[Shadrach Loom]

Re 11, and as far as I can see from my own experience and quite a bit of googling, UK prostate pathways seem perfectly sensible already: PSA tests and the arsefinger probe may raise clinical suspicion, but multi-parametric MRIs are the first port of call before any invasive biopsies are carried out, and watchful waiting or active surveillance are preferred to radical options unless there is good reason. It’s only in the US that testing and biopsies seem to be ubiquitous.

 

[Jaybee00]

https://bmjopen.bmj.com/content/bmjopen/11/5/e047993.full.pdf

PI here Thomas Foltynie is from UCL. @Jonathan Edwards any chance you know him? If yes, I’m curious to know if they believe that exenatide in particular has positive neuro effects or whether they believe that all GLP1 agonists would also have beneficial neurological effects. Thanks.