‘Stomach-ache’ neurons rush to the rescue when bacteria invade

Discussion in 'Other health news and research' started by Andy, Dec 16, 2019.

  1. Andy

    Andy Committee Member

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    https://www.nature.com/articles/d41586-019-03725-8

    The paper itself: Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense
    Paywall, https://www.cell.com/cell/fulltext/S0092-8674(19)31270-X
    Sci hub, https://sci-hub.se/10.1016/j.cell.2019.11.014
     
  2. rvallee

    rvallee Senior Member (Voting Rights)

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    An interesting question would be how common it is to ingest a small number of not-particularly-vibrant salmonella bacteria (or any other that generate a similar nociceptive response) and whether this could be a rather common cause of digestive pain, whether there is a threshold that will not trigger a full evacuation but still lead to what some people would qualify as IBS or something like it. Especially considering how unfortunately common it is to find fecal bacteria and other types of nasties in food.

    Depends of course on beliefs about pain, though, whether people who believe pain does not actually exist without injury have some thoughts and beliefs about what the salmonella are thinking, or something like that. Somehow I don't think either of the bacteria or the watchful neurons will be particularly receptive to CBT, then again I'm sure someone will come up with a way to make the case that, at the very least, more research is needed to figure out how to change the germs' bad behavior.
     
    Amw66 likes this.

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