There's been quite a few studies over the years showing mental health comorbidities in ME/CFS; here are some: On psychiatric interview, 35% met a diagnosis of major depressive disorder, and 29% had an anxiety disorder. 1 Depression 47% and anxiety 39%. 1 Major depression 11%, generalized anxiety disorder 13%, and panic disorder 7%. 1 MEA survey of 4,217 patients: 46% reported depression and 38% anxiety or panic attacks as major problem (page 8). 1 There was also a poll on Phoenix Rising asking patients if they were depressed, and 38% said they were.