Øystein Fluge and Olav Mella's ME/CFS research

Rituximab (RituxME)

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series
Øystein Fluge and Olav Mella
BMC Neurology
2009
Link to article

Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study
Øystein Fluge, Ove Bruland, Kristin Risa, Anette Storstein, Einar K. Kristoffersen, Dipak Sapkota, Halvor Næss, Olav Dahl, Harald Nyland, Olav Mella
Plos One
2011
Link to article

B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment
Øystein Fluge, Kristin Risa, Sigrid Lunde, Kine Alme, Ingrid Gurvin Rekeland, Dipak Sapkota, Einar Kleboe Kristoffersen, Kari Sørland, Ove Bruland, Olav Dahl, Olav Mella
Plos One
2015
Link to article

Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome.
Lunde S, Kristoffersen EK, Sapkota D, Risa K, Dahl O, Bruland O, Mella O, Fluge Ø
PLoS One.
2016
Link to article

Clinical trial registration
B-lymphocyte Depletion Using Rituximab in Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME). A Randomized Phase-III Study. (RituxME)
Link to registration
Though the trial has not been published yet, the principal investigators, Fluge and Mella, announced that the results of the study were negative: see S4ME thread

Cyclophosphamide (CycloME)

Clinical trial registration
Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS) (CycloME)
2015
Link to registration

Immunity

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome.
Loebel M, Grabowski P, Heidecke H, Bauer S, Hanitsch LG, Wittke K, Meisel C, Reinke P, Volk HD, Fluge Ø, Mella O, Scheibenbogen C.
Brain Behav Immun.
2016
Link to article

Metabolism

Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome.
Fluge Ø, Mella O, Bruland O, Risa K, Dyrstad SE, Alme K, Rekeland IG, Sapkota D, Røsland GV, Fosså A, Ktoridou-Valen I, Lunde S, Sørland K, Lien K, Herder I, Thürmer H, Gotaas ME, Baranowska KA, Bohnen LM, Schäfer C, McCann A, Sommerfelt K, Helgeland L, Ueland PM, Dahl O, Tronstad KJ
JCI Insight.
2016 Dec 22
Link to article

Videos

Olav Mella speaks about the Rituximab study and ME/CFS future
2014
Link to video

The RituxME and CycloME studies – Ongoing Clinical Research in the ME/CFS Research Group
2016
Link to video

From insight to change
TEDxTrondheim
Maria Gjerpe
2016
A medical doctor, Maria Gjerpe was part of a pilot Rituximab study by Dr. Fluge and Mella.
Link to video
S4ME thread

Podcast

Is ME an autoimmune disease?
The Naked Scientists
2015
Link to Podcast