uk biobank

The UK Biobank resource with deep phenotyping and genomic data Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T. Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O’Connell, Adrian Cortes, Samantha Welsh, Alan Young, Mark Effingham, Gil McVean...

Abstract: Major depressive disorder (MDD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently occur together; yet their causal relationship remains unclear. To investigate the potential genetic causal link between these conditions, we conducted a two-sample Mendelian...

Refinement of post-COVID condition core symptoms, subtypes, determinants, and health impacts: a cohort study integrating real-world data and patient-reported outcomes Yunhe Wang; Marta Alcalde-Herraiz; Kim López Güell; Li Chen; Lourdes Mateu; Chunxiao Li; Raghib Ali; Nicholas Wareham; Roger...

Katherine Huang, Alex G. C. de Sá, Natalie Thomas, Robert D. Phair, Paul R. Gooley, David B. Ascher & Christopher W. Armstrong Abstract Background Diagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and...

Link: https://www.cell.com/cell/fulltext/S0092-8674(24)01268-6 Highlights • Construct a comprehensive proteomics atlas for 1,706 human diseases and traits • Machine-learning-based big data uncover promising diagnostic and predictive biomarkers • Identify 37 drug repurposing prospects and 26...

rest of article from the Guardian Concerns raised over access to UK Biobank data after ‘race scientists’ claims

Absence of Association between a Long COVID and Severe COVID-19 Risk Variant of FOXP4 and Lung Cancer Luo, Yu-Si; Zhang, Ke; Cheng, Zhong-Shan No abstract. Link | PDF (Frontiers in Genetics)

Observer investigation reveals UK Biobank opened its biomedical database to insurance firms despite pledge it would not do so Sensitive health information donated for medical research by half a million UK citizens has been shared with insurance companies despite a pledge that it would not be...

https://ourfuturehealth.org.uk/millions-of-invitations-go-out-this-autumn-for-uks-largest-health-research-programme/ Our Future Health | 24.10.22 Over three million letters are being sent out this autumn inviting members of the public to join Our Future Health, a major new health research...

ABSTRACT Objective To examine association of COVID-19 with incident cardiovascular events in 17 871 UK Biobank cases between March 2020 and 2021. Methods COVID-19 cases were defined using health record linkage. Each case was propensity score-matched to two uninfected controls on age, sex...

published paper posted on this thread here Preprint Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease that lacks known pathogenesis, distinctive diagnostic criteria, and effective treatment options. Understanding the genetic...

Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic diversity depends on a comprehensive and reliable characterization of both sequences and phenotypic variation. Over the past decade, insights into this relationship have been obtained from whole-exome...

Abstract Objectives: Chronic pain is often experienced alongside other long-term conditions (LTCs), yet our understanding of this, particularly in relation to multimorbidity (≥2 LTCs) is poor. We aimed to examine associations between the presence/extent of chronic pain with type/number of LTCs...

Associations between long-term conditions and upper gastrointestinal cancer incidence: A prospective population-based cohort of UK Biobank participants Abstract Upper gastrointestinal cancers (oesophageal/stomach) have high mortality rates and are often diagnosed after the disease has...

" Abstract Importance Psychotic experiences, such as hallucinations and delusions, are reported by approximately 5%-10% of the general population, though only a small proportion develop psychotic disorders such as schizophrenia. Studying the genetic aetiology of psychotic experiences in the...

Guest blog by Professor Chris Ponting and colleagues at ME/CFS Research Review UK Biobank - a national biobank different from the ME/CFS biobank - has data from around 500,000 individuals, including both healthy people and those with one or more of the many different diseases in the UK...

Note: the UK Biobank is not the same as the UK ME/CFS Biobank. Open access at https://www.nature.com/articles/s41467-018-03819-3

So the official event thread is here, https://www.s4me.info/index.php?threads/uk-me-cfs-biobank-ask-me-anything-thread-thursday-14th-december-2017-2-30-to-3-30pm-gmt-utc.1458/, but this thread is here to allow discussion of it before hand, so discuss away... :)