tgf-beta

TGF-β inhibitor SB431542 suppresses coronavirus replication through multistep inhibition Assim Verma; Garvit Kumar; Nitin Khandelwal; Benjamin E Mayer; Jitender Rathee; Yogesh Chander; Alka Nokhwal; Shweta Dhanda; Ram Kumar; Himanshu Kamboj; Riyesh Thachamvally; Shalini Sharma; Naveen Kumar The...

Abstract In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion2 and systemic...

Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID Thuc Duy Le, Sindy Licette Pinero, Xiaomei Li, Lin Liu, Jiuyong Li, Sang Hong Lee, Marnie Winter, Thin Nguyen, Junpeng Zhang Background Long COVID, or Post–Acute Sequelae of COVID–19 (PASC), involves persistent...

Abstract: Background: Epstein-Barr virus (EBV) infection is a known trigger and risk factor for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we found enhanced IgG reactivity to EBV EBNA4 and EBNA6 arginine-rich sequences in...

Vascular fibrosis and extracellular matrix remodelling in post-COVID 19 conditions Kamdar; Sykes; Thomson; Mangion; Ang; Lee; Van Agtmael; Berry Causal associations between viral infections and acute myocardial injury are not fully understood, with mechanisms potentially involving direct...

Endogenous self-peptides guard immune privilege of the central nervous system Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F. M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe...

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients Shahbaz; Rezaeifar; Syed; Redmond; Terveart; Osman; Elahi A substantial portion of patients infected with SARS-CoV-2 experience prolonged complications...

Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus Law, Calvin; Wacleche, Vanessa Sue; Cao, Ye; Pillai, Arundhati; Sowerby, John; Hancock, Brandon; Horisberger, Alice; Bracero, Sabrina; Skidanova, Viktoriya; Li, Zhihan; Adejoorin, Ifeoluwakiisi; Dillon, Eilish; Benque, Isaac...

The extracellular matrix integrates mitochondrial homeostasis Hanlin Zhang; C. Kimberly Tsui; Gilberto Garcia; Larry K. Joe; Haolun Wu; Ayane Maruichi; Wudi Fan; Sentibel Pandovski; Peter H. Yoon; Brant M. Webster; Jenni Durieux; Phillip A. Frankino; Ryo Higuchi-Sanabria; Andrew Dillin SUMMARY...

Chronic fatigue syndrome and circulating cytokines: A systematic review S Blundell, KK Ray, M Buckland, PD White There has been much interest in the role of the immune system in the pathophysiology of chronic fatigue syndrome (CFS), as CFS may develop following an infection and cytokines are...

Sex differences and immune correlates of Long COVID development, persistence, and resolution Rebecca E Hamlin; Shaun M Pienkos; Leslie Chan; Mikayla A Stabile; Kassandra Pinedo; Mallika Rao; Philip Grant; Hector Bonilla; Marisa Holubar; Upinder Singh; Karen B Jacobson; Prasanna Jagannathan...

Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome Saito; Shahbaz; Osman; Redmond; Bozorgmehr; Rosychuk; Lam; Sligl; Cohen Tervaert; Elahi A substantial number of patients recovering from acute SARS-CoV-2...

NK cell-monocyte crosstalk underlies NK cell activation in severe COVID-19 Madeline J Lee; Izumi de los Rios Kobara; Trisha R Barnard; Xariana Vales Torres; Nicole H Tobin; Kathie G Ferbas; Anne W J Rimoin; Otto O Yang; Grace M Aldrovandi; Aaron James Wilk; Jennifer Fulcher; Catherine A Blish...

A 50-gene high-risk profile predictive of COVID-19 and Idiopathic Pulmonary Fibrosis mortality originates from a molecular imbalance in monocyte and T-cell subsets that reverses in survivors with post-COVID-19 Interstitial Lung Disease Bochra Tourki; Minxue Jia; Theodoros Karampitsakos; Iset M...

The JAK/STAT signaling pathway: from bench to clinic Hu, Xiaoyi; li, Jing; Fu, Maorong; Zhao, Xia; Wang, Wei The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular...

Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment Stuelten, Christina H.; Zhang, Ying E. Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early...

Preprint Blood-brain barrier disruption in Long COVID-associated cognitive impairment Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell Vascular disruption has been...