Posting several links exploring temporal dynamics between interferon, autoantibodies, and autoimmune diseases (primarily lupus).
(Review) Emerging concepts of type I interferons in SLE pathogenesis and therapy
Note: SLE = systemic lupus erythematosus
Links to references are active in the...
Improved Fatigue Management in Primary Sjögren's Syndrome: A Retrospective Analysis of the Efficacy of Methotrexate in Chinese Patients
Meiju Zhou, Xiaona Dai, Fang Yuan
Abstract
Objective: To assess the efficacy of methotrexate (MTX) and hydroxychloroquine (HCQ) in improving fatigue...
Epstein–Barr virus as a potentiator of autoimmune diseases
William H. Robinson, Shady Younis, …Tobias V. Lanz Show authors
Nature Reviews Rheumatology (2024)Cite this article
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Abstract
The Epstein–Barr virus (EBV) is epidemiologically associated with development of autoimmune...
Interferon gene expression declines over time post-COVID infection and in long COVID patients
A. Gómez-Carballa; S. Pischedda; J. Pardo-Seco; J. Gómez-Rial; F. Martinón-Torres; A. Salas
BACKGROUND
Interferons (IFNs) represent a first-line defense against viruses and other pathogens. It has been...
Exploring the clinical and immunopathological association between Long COVID and Sjögren's Disease in mice and humans
Sponsored by: Olink Proteomics
+25pts
SPEAKER
Cuong Nguyen, PhD
Associate Professor, University of Florida
BIOGRAPHY
EVENT DATE & TIME
Date: May 30, 2024
Time: 9:00 AM...
Full title: Identification of distinct subgroups of Sjögren's disease by cluster analysis based on clinical and biological manifestations: data from the cross-sectional Paris-Saclay and the prospective ASSESS cohorts
Summary
Background
Sjögren's disease is a heterogenous autoimmune disease...
https://pubmed.ncbi.nlm.nih.gov/37147113/
Abstract
Objective: Identify autoantibodies in anti-Ro/SS-A negative primary Sjögren's syndrome (SS).
Methods: This is a proof-of-concept, case-control study of SS, healthy (HC) and other disease (OD) controls. A discovery dataset of plasma samples...
Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome
ABSTRACT NUMBER: 2546
Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome
Lakshmanan Suresh1, Julian Ambrus2, Long Shen3 and Sahana Vishwanath4, 160 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, 2100 High St...
LB0003 Dazodalibep (VIB4920/HZN4920) in Sjögren’s Subjects with an Unacceptable Symptom Burden: Safety and Efficacy from a Phase 2, Randomized, Double-Blind Study
Abstract
Background Sjögren’s is a systemic autoimmune disease associated with marked morbidity and poor health-related quality of...
Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19
Sung Ha Lim; Hyun Jeong Ju; Ju Hee Han; Ji Hae Lee; Won-Soo Lee; Jung Min Bae; Solam Lee
Importance
Multiple cases of autoimmune and autoinflammatory diseases after COVID-19 have been reported. However, their...
https://rmdopen.bmj.com/content/9/3/e003464
Here, we report the first two cases of patients with severe complications of SjD, refractory to RTX and successfully treated with daratumumab.
Abstract:
Fatigue is the most commonly reported and debilitating extraglandular symptom of primary Sjögren′s syndrome (pSS). Fatigue and exertional intolerance are hallmark symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
We aimed to characterize fatigue and further...
Evidence of a Sjögren’s disease-like phenotype following COVID-19
Objectives Sjögren’s Disease (SjD) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration and the development of dry eyes and dry mouth resulting from the secretory dysfunction of the exocrine...
Introduction: Viral infection is an exogeneous factor for primary Sjogren’s syndrome (pSS). This study investigated the association between human papillomavirus (HPV) infections and pSS through a nationwide population based cohort study.
Methods: Patients with HPV infections between January...
Abstract
Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints.
Only pSS...
Highlights
• Chronic inflammation can be caused by organelle (e.g., mitochondria) malfunction.
• Dysfunctional mitochondria release DAMPs that trigger inflammation through PRRs.
• Salivary cells’ mitochondria show ultrastructural alterations in Sjögren’s syndrome.
• Endoplasmic reticulum...
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