review

Abstract The previous acute respiratory diseases caused by viruses originating from China or the middle east (e.g., SARS, MERS) remained fast developing short diseases without major sequalae or any long-lasting complications. The new COVID-19, on the other hand, not only that it rapidly spread...

Metabolic Instruction of Immunity Michael D. Buck; Ryan T. Sowell; Susan M. Kaech; Erika L. Pearce Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and...

Free fulltext: https://www.mdpi.com/1660-4601/20/4/3477 Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review by by Joht Singh Chandan 1,*,Kirsty R. Brown 1,2,Nikita Simms-Williams 1,Nasir Z. Bashir 3,Jenny Camaradou 4,Dominic Heining 5,Grace M...

Tissue injury and leukocyte changes in post-acute sequelae of SARS-CoV-2: review of 2833 post-acute patient outcomes per immune dysregulation and microbial translocation in long COVID Abstract A significant number of persons with coronavirus disease 2019 (COVID-19) experience persistent...

Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner & Mark A. Horowitz The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or...

Full title: What psychological interventions are effective for the management of persistent physical symptoms (PPS)? A systematic review and meta-analysis Abstract Objectives Presentation of persistent physical symptoms is associated with increased health care utilization, yet clinical...

Abstract Objective We conducted literature reviews to uncover differential effects of sex on sequelae from coronavirus disease 2019 (COVID-19) and on long COVID syndrome. Methods Two authors independently searched OvidSP in Embase, Medline, Biosis, and Derwent Drug File. Publications reporting...

Abstract Background At the 2015 REWARD/EQUATOR conference on research waste, the late Doug Altman revealed that his only regret about his 1994 BMJ paper ‘The scandal of poor medical research’ was that he used the word ‘poor’ rather than ‘bad’. But how much research is bad? And what would...

(an old paper, mentioned on another thread here) Interventions for the Treatment and Management of Chronic Fatigue Syndrome: A Systematic Review https://jamanetwork.com/journals/jama/article-abstract/194209 Penny Whiting, MSc; 1 Anne-Marie Bagnall, PhD; 1 Amanda J. Sowden, PhD; 1 John E...

Title : N-Acetylcysteine to Combat COVID-19: An Evidence Review Link : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649937/ Abstract The novel coronavirus disease (COVID-19) is caused by a virus (SARS-Cov-2) and is known for inducing multisystem organ dysfunction associated with significant...

[Yet another pointless FND review paper] Abstract Functional neurological disorder and somatic symptom disorder are complex neuropsychiatric conditions that have been linked to circuit-based dysfunction of brain networks. Neuromodulation is a novel therapeutic strategy capable of modulating...

Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials. A Systematic Review and Meta-analysis Julia W. Haas, PhD1,2; Friederike L. Bender, MS3; Sarah Ballou, PhD1,2; John M. Kelley, PhD1,4; Marcel Wilhelm, PhD3; Franklin G. Miller, PhD5; Winfried Rief, PhD3; Ted J...

Abstract Long-Covid (LC), as a patient-defined illness, has rapidly emerged as both a medical and social issue since 2020, drawing headlines in the public and global domain. In the UK, people experiencing ongoing symptoms of Covid after the initial infection came together online to try to make...

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disorder of unknown physiopathology with multisystemic repercussions, framed in ICD-11 under the heading of neurology (8E49). There is no specific test to support its clinical diagnosis. Our objective is to review the...

Abstract This is a comprehensive literature review of chronic fatigue syndrome (CFS). We provide a description of the background, etiology, pathogenesis, diagnosis, and management regarding CFS. CFS is a multifaceted illness that has many symptoms and a wide array of clinical presentations. As...

Highlights • ME/CFS, a clinical entity of unknown etiology characterized by PEM, is easily diagnosed when following available guidelines. • Patients with ME/CFS typically have small hearts, low stroke volume, and low total blood volume, and some have OI. • More studies are needed to understand...

Abstract Although most patients recover from acute COVID-19, some experience postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of PASC is a syndrome called “long COVID-19,” reminiscent of myalgic encephalomyelitis/chronic fatigue syndrome...

Abstract Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on the lives and health of people around the globe. As of 4 July 2021, more than 183 million confirmed cases of covid-19 had been recorded worldwide, and 3.97 million deaths. Recent evidence has shown...

Objective: Several studies suggested that Qigong exercise (QE) can relieve fatigue in patients diagnosed with various diseases. Our review aimed to evaluate the efficacy of QE for alleviating fatigue. Methods: A related literature search was performed in the PubMed, Web of Science, Embase...

Abstract Background and Objectives: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic condition distinguished by disabling fatigue associated with post-exertional malaise, as well as changes to sleep, autonomic functioning, and cognition. Mind-body interventions (MBIs)...