persistence

Saw this posted from Science Translational Medicine (a reputable journal), and thought it looked exciting. I also note liver involvement - there are some reports of liver issues in some people with ME… Interested to know what people think. Abstract Persistent symptoms after an acute infection...

Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection Michael J. Peluso; Zoe N. Swank; Sarah A. Goldberg; Scott Lu; Thomas Dalhuisen; Ella Borberg; Yasmeen Senussi; Michael A. Luna; Celina Chang Song; Alexus Clark; Andhy Zamora; Megan Lew; Badri Viswanathan; Beatrice...

https://journals.asm.org/doi/10.1128/iai.00034-16 ABSTRACT Rickettsioses are emerging febrile diseases caused by obligate intracellular bacteria belonging to the family Rickettsiaceae. Rickettsia typhi belongs to the typhus group (TG) of this family and is the causative agent of endemic typhus...

Abstract Background: Some investigators believe that a proportion of chronically unwell patients, many with fatigue, have an underlying rickettsial disease. Aim: To investigate the prevalence of markers of rickettsial infection in patients with chronic illnesses. Design: Observational study...

Abstract Retrograde menstruation is a widely accepted cause of endometriosis. However, not all women who experience retrograde menstruation develop endometriosis, and the mechanisms underlying these observations are not yet understood. Here, we demonstrated a pathogenic role of Fusobacterium...

Recent Advances on the Innate Immune Response to Coxiella burnetii Guido Sireci, 1 Giusto Davide Badami, 1 Diana Di Liberto, 1 Valeria Blanda, 2 , * Francesca Grippi, 2 Laura Di Paola, 2Annalisa Guercio, 2 José de la Fuente, 3 , 4 and Alessandra Torina 2 Abstract Coxiella burnetii is an...

Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses Spatola, Marianna; Nziza, Nadège; Jung, Wonyeong; Deng, Yixiang; Yuan, Dansu; Dinoto, Alessandro; Bozzetti, Silvia; Chiodega, Vanessa; Ferrari, Sergio; Lauffenburger, Douglas A; Mariotto, Sara...

Highlights• Cellular stress provokes activation of viral replication in an RNA virus model The viral replication factories are liquid-like condensates that coarsen under stress Stress-triggered IDR phosphorylation stabilizes the viral replication machinery In-cell nucleocapsid structures reveal...

https://www.nature.com/articles/s41564-023-01349-3 The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Previous studies show...

EBV dUTPase: A Novel Modulator of Inflammation and the Tumor Microenvironment in EBV-Associated Malignancies Williams, Marshall V.; Mena-Palomo, Irene; Cox, Brandon; Ariza, Maria Eugenia There is increasing evidence that put into question the classical dogma that the Epstein–Barr virus (EBV)...

Abstract Ebola virus (EBOV) causes severe hemorrhagic fever in humans with high mortality. In Ebola virus disease (EVD) survivors, EBOV persistence in the eyes may break through the inner blood–retinal barrier (iBRB), leading to ocular complications and EVD recurrence. However, the mechanism by...

https://www.mdpi.com/1999-4915/13/8/1673 The Post-Acute Phase of SARS-CoV-2 Infection in Two Macaque Species Is Associated with Signs of Ongoing Virus Replication and Pathology in Pulmonary and Extrapulmonary Tissues Primarily a Dutch study Biomedical Primate Research Centre (BPRC), Department...

Preprint Abstract COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC)4-5. However, the burden of infection outside the respiratory tract and time to viral clearance is...

Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome Eirini Apostolou, Muhammad Rizwan, Petros Moustardas, Per Sjögren, Bo Christer Bertilson, Björn Bragée, Olli Polo and Anders...

A 63-year-old woman presented with dyspepsia and gastric pain without B symptoms. She had been treated with methotrexate for 8 years for psoriatic arthritis. Endoscopy showed multiple gastric ulcers. Histological examination revealed submucosal infiltration by small- to medium-size lymphoid...

Full title: At the Root of 3 “Long” Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome ABSTRACT: Several foreign antigens such as those derived from viruses and bacteria have been linked to...

Abstract Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency and reactivation1,2. A long appreciated, yet undefined relationship exists between the lytic–latent switch and viral non-coding RNAs3,4. Here we identify viral...

Abstract Background and aims: The coronavirus disease 2019 (COVID-19) pandemic affects populations, societies and lives for more than two years. Long-term sequelae of COVID-19, collectively termed the post-acute COVID-19 syndrome, are rapidly emerging across the globe. Here, we investigated...

"UK doctors believe they have documented the longest Covid infection on record - a patient they treated who had detectable levels of the virus for more than 16 months, or 505 days, in total. ..... This is different to "long Covid", where the virus is cleared from the body but symptoms persist."...

https://www.cell.com/med/fulltext/S2666-6340(22)00167-2 Highlights 1.Approximately half of COVID-19 patients shed fecal RNA in the week after infection 2. 4% patients with COVID-19 shed fecal viral RNA 10 months after diagnosis. 3. Presence of fecal SARS-CoV-2 RNA is associated with...