peroxiredoxin

Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia Fang; Zhang; Xu; Wang; He; Liao; Yuan; Tang Schizophrenia is a severe and clinically heterogeneous mental disorder, with approximately 30 % of patients developing treatment resistance to standard...

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation Interferon-stimulated gene 15 (ISG15) regulates diverse cellular responses including antiviral immunity through its conjugation to proteins, a process known as ISGylation. Several pathogens, including...

One of the candidate genes in the DecodeME preprint. Curcumin increases PRDX6 expression.

Molecular Insights into Long COVID: Plasma Proteomics Reveals Oxidative Stress, Coagulation Cascade Activation, and Glycolytic Imbalance Sheela Ramanathan; Mohammad Mobarak Hussain Chowdhury; Akouavi Julite Irmin Quenum; Christine Rioux-Perreault; Jean-Francois Lucier; Subburaj Ilangumaran...

Highlights -The peroxiredoxin Tsa1 interacts with a large fraction of the proteome in a redox manner -Covalent Tsa1 attachment to target proteins (peroxiredoxinylation) increases upon stress -Metabolic enzymes and proteins involved in translation are targeted by Tsa1 -Stress survival requires...

Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...

A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages. Paywalled

Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition Mobin Khoramjoo; Kaiming Wang; Karthik Srinivasan; Mahmoud Gheblawi; Rupasri Mandal; Simon Rousseau; David Wishart; Vinay Prasad; Lawrence Richer; Angela M. Cheung; Gavin Y. Oudit BACKGROUND A subset...

Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches Molnar, Tihamer; Lehoczki, Andrea; Fekete, Monika; Varnai, Reka; Zavori, Laszlo; Erdo-Bonyar, Szabina; Simon, Diana; Berki, Tímea; Csecsei, Peter; Ezer, Erzsebet The COVID-19 pandemic, caused...

Can inflammatory plasma proteins predict Long COVID or Fatigue severity after SARS-CoV-2 infection? Schmitz; Freuer; Goßlau; Warm; Hyhlik-Dürr; Linseisen; Meisinger; Kirchberger OBJECTIVES To investigate whether specific immune response plasma proteins can predict an elevated risk of developing...

https://www.researchsquare.com/article/rs-3335919/v1 Article Immune cell proteomes of Long COVID patients have functional changes similar to those in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Katie Peppercorn1 Christina D. Edgar1 Torsten Kleffmann1 Warren. P Tate1 Email 1...

A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction https://www.researchsquare.com/article/rs-52172/v1