Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response
Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19
Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...
Redefining the role of Hypoxia-inducible factors HIFs in oxygen homeostasis
Clemente Fernández Arias; Franciso J Acosta; Federica Bertocchini; Cristina Fernández-Arias
Hypoxia-inducible factors (HIFs) are key regulators of intracellular oxygen homeostasis. The marked increase in HIFs activity...
acetyl co a
glycolysis
hif-1
hypoxia
hypoxic stress
lactate
metabolix
oxidativephosphorylationoxidative stress
pyruvate
reverse electron transport
warburg effect
Mitochondrial morphology and function in mitochondrial disease
Julie Faitg; Tracey Davey; Ross Laws; Conor Lawless; Helen Tuppen; Eric Fitton; Doug Elizabeth Turnbull; Amy Elizabeth Vincent
Mitochondria play a crucial role in maintaining cellular health. It is interesting that the shape of...
Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity
Vermeulen, Ruud CW; Kurk, Ruud M; Visser, Frans C; Sluiter, Wim; Scholte, Hans R
Background
The aim of this study was to investigate...
Reduced athletic performance post-COVID-19 is associated with reduced anaerobic threshold
Robert M Barker-Davies; Peter Ladlow; Rebecca Chamley; Edward Nicol; David A Holdsworth
Detailed characterisation of cardiopulmonary limitations in patients post-COVID-19 is currently limited, particularly...
Primary oxidative phosphorylation defects lead to perturbations in the human B cell repertoire
Gordon-Lipkin, Eliza M.; Banerjee, Payal; Franco, Jose Luis Marin; Tarasenko, Tatiana; Kruk, Shannon; Thompson, Elizabeth; Gildea, Derek E.; Zhang, Suiyuan; Wolfsberg, Tyra G.; NISC Comparative...
Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment
Stuelten, Christina H.; Zhang, Ying E.
Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early...
Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration
Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext
An old study but, as shown in this thread, https://s4me.info/threads/top-10-sc...f-citations-tweet-by-dr-mark-gutheridge.7461/, one of the most cited ME/CFS papers in the past 10 years, so thought it might be useful to have here.
Open access at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/
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