nitric oxide

Study links oral microbiome to cognitive function in older adults

340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park Background As the number of COVID-19 survivors amongst the global population continues to rise, the...

The physio-affective symptoms of Long COVID are strongly predicted by the severity of the acute infectious phase, and lowered antioxidant, nitric oxide, and alanine transaminase levels Michael Maes, Chavit Tunvirachaisakul, Laura de Oliveira Semão, Ana Paula Michelin, Andressa Matsumoto...

Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can reactivate during acute illnesses. Recent...

Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...

Follow-up assessment of the microvascular function in patients with long COVID Romanowska-Kocejko; Braczko; Jędrzejewska; Żarczyńska-Buchowiecka; Kocejko; Kutryb-Zając; Hellmann Long COVID is a complex pathophysiological condition. However, accumulating data suggests that COVID-19 is a systemic...

Inhibition of HIF-2α Pathway as a Potential Therapeutic Strategy for Endothelial Dysfunction in Post-COVID Syndrome Andrea Ribeiro; Timon Kuchler; Maciej Lech; Javier Carbajo-Lozoya; Kristina Adorjan; Hans Christian Stubbe; Martina Seifert; Anna Wöhnle; Veronika Kesseler; Johanna Negele; Uwe...

Abstract Background This study investigates the impact of fluctuating lipid levels on endothelial dysfunction. Methods Human aortic and umbilical vein endothelial cells were cultured under varying palmitic acid (PA) concentrations: 0, 50, and 100 μM, and in a variability group alternating...

Disuse-Induced Muscle Fatigue: Facts and Assumptions Sergeeva, Xenia V.; Lvova, Irina D.; Sharlo, Kristina A. Skeletal muscle unloading occurs during a wide range of conditions, from space flight to bed rest. The unloaded muscle undergoes negative functional changes, which include increased...

Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID Romanowska-Kocejko, Marzena; Jędrzejewska, Agata; Braczko, Alicja; Stawarska, Klaudia; Król, Oliwia; Frańczak, Marika; Harasim, Gabriela; Smoleński, Ryszard T.; Hellmann, Marcin; Kutryb-Zając...

Indole-3-propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells Geddo, Federica; Antoniotti, Susanna; Gallo, Maria Pia; Querio, Giulia Different gut microbiota-derived metabolites...

Full Title: Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 with and without POTS syndrome; a multi-omic profiling study, 2023, Ali Mahdi et al Abstract Post-acute COVID-19 (PACS) are associated with cardiovascular dysfunction, especially...

People With Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Exhibit Similarly Impaired Vascular Function Background This study aimed to compare flow-mediated dilation values between individuals with Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome...

COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway Ali Mroueh; Walaa Fakih; Adrien Carmona; Antonin Trimaille; Kensuke Matsushita; Benjamin Marchandot; Abdul Wahid Qureshi; Dal-Seong Gong; Cyril Auger; Laurent Sattler...

Exercise and vascular function in sedentary lifestyles in humans Fasipe, Babatunde; Li, Shunchang; Laher, Ismail People with sedentary lifestyles engage in minimal or no physical activity. A sedentary lifestyle promotes dysregulation of cellular redox balance, diminishes mitochondrial function...

Hello all, During my research, I've become interested in a specific protein, which is called NFAT5 (or also TonEBP) and which I think might be linked to ME/CFS. Here is why I think it could be the case: Response to osmotic stress Ronald Davis developed a test that works by submitting cells...

Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation Timon Kuchler; Roman Günthner; Andrea Ribeiro; Renate Hausinger; Lukas Streese; Anna Wöhnl; Veronika Kesseler; Johanna Negele; Tarek Assali; Javier Carbajo-Lozoya...

Abstract Background: Neurovascular coupling (NVC) is a key process in cerebral blood flow regulation. NVC ensures adequate brain perfusion to changes in local metabolic demands. Neuronal nitric oxide synthase (nNOS) is suspected to be involved in NVC; however, this has not been tested in...

Significance ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain undefined. In this study, we identify primary ChAT+ T cells in patients...

Immunometabolic rewiring in long COVID patients with chronic headache Suan-Sin Foo, Weiqiang Chen, Kyle L Jung, Tamiris Azamor, Un Yung Choi, Pengfei Zhang, Suzy AA Comhair, Serpil C Erzurum, Lara Jehi, Jae U Jung Almost 20% of patients with COVID-19 experience long-term effects, known as...