neuroimmune

A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response...

Evidence for a role of skull bone marrow in human chronic pain as revealed by TSPO PET imaging The skull bone marrow is emerging as a critical hub for neuroimmune signaling in various disorders, with the potential to reshape how we understand brain-immune interactions. However, its role in...

Abstract: Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ...

I seem to have weeks going into months of brain inflammation which is horrendous. My brain feels inflamed which at night particularly seems to go throughout my body, some of the day as well. The feeling is deeply uncomfortable and quite excruciatingly painful with some throbbing, spreads across...

Neuropsychiatric manifestations of Long COVID Shashank Saurabh Sinha, Saarim Bari, Pranjal Tripathi, Surya Kant, Shailendra Mohan Tripathi [Line breaks added] Highlights • More common with severe COVID • Dysregulated immune response main pathogenetic mechanism. • Headache...

Full title: Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 Rebeka Fekete, Alba Simats, Eduárd Bíró, Balázs Pósfai, Csaba Cserép, Anett D. Schwarcz, Eszter Szabadits, Zsuzsanna Környei, Krisztina...

The neuroimmune connectome in health and disease Wheeler, Michael A.; Quintana, Francisco J. The nervous and immune systems have complementary roles in the adaptation of organisms to environmental changes. However, the mechanisms that mediate crosstalk between the nervous and immune systems...

Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics Talkington, Grant McGee; Kolluru, Paresh; Gressett, Timothy E.; Ismael, Saifudeen; Meenakshi, Umar; Acquarone, Mariana; Solch-Ottaiano, Rebecca J.; White, Amanda...

Endogenous self-peptides guard immune privilege of the central nervous system Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F. M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe...

Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis Martina Rubin; Paolo Preziosa; Monica Margoni; Alessandro Meani; Elisabetta Pagani; Gianluca Corazzolla; Loredana Storelli; Damiano Mistri; Massimo Filippi; Maria A Rocca...

Molecular overlaps of neurological manifestations of COVID-19 and schizophrenia from a proteomic perspective Antunes, André S. L. M.; Reis-de-Oliveira, Guilherme; Martins-de-Souza, Daniel COVID-19, a complex multisystem disorder affecting the central nervous system, can also have psychiatric...

Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach Background: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact...

Neat1 lncRNA organizes the inflammatory gene expressions in the dorsal root ganglion in neuropathic pain caused by nerve injury Maruyama, Motoyo; Sakai, Atsushi; Fukunaga, Tsukasa; Miyagawa, Yoshitaka; Okada, Takashi; Hamada, Michiaki; Suzuki, Hidenori Primary sensory neurons regulate...

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground? Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown etiology, sharing a similar clinical presentation with the increasingly...

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiologic agent of the coronavirus disease 2019 (COVID-19), is now rapidly disseminating throughout the world with 147,443,848 cases reported so far. Around 30–80% of cases (depending on COVID-19 severity) are reported...

"The nervous and immune systems are tightly intertwined. Deciphering their chatter might help address many brain disorders and diseases." There is a lot more in the article about the brain, neuroimmunology, microglia, sickness behaviour, Alzheimer's, MS, etc, but this is the part that caught my...

https://www.nature.com/articles/s41582-021-00496-7

Description: Jessica Maya, a graduate student in the Genetics, Genomics, and Development Program at Cornell University in Maureen Hanson’s lab, talks about ME/CFS, the immune system response, and the fuels that energize immune cells to properly defend the body. This talk was adapted from...

Full title: The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups https://www.preprints.org/manuscript/202101.0623/v1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ Abstract: