mtor

  1. InitialConditions

    Stress dynamically modulates neuronal autophagy to gate depression onset - Yang et al., 2025

    Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders. As a key modulator of brain homeostasis, it remains elusive whether and how brain autophagy is engaged in stress dynamics. Here we discover that acute stress activates, whereas chronic stress...
  2. forestglip

    Trial Report Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy, 2025, Ruan et al

    Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy Brian T. Ruan, Sarojini Bulbule, Amy Reyes, Bela Chheda, Lucinda Bateman, Jennifer Bell, Braydon Yellman, Stephanie Grach, Jon Berner, Daniel L. Peterson, David Kaufman, Avik Roy...
    • forestglip
    • Thread
    • atg13 autophagy beclin-1 me/cfs mtor pser258-atg13 rapamycin
    • Replies: 34
    • Forum: ME/CFS research
  3. forestglip

    Opinion mTORC1 syndrome (TorS): unifying paradigm for PASC, ME/CFS and PAIS, 2025, Bar-Tana

    mTORC1 syndrome (TorS): unifying paradigm for PASC, ME/CFS and PAIS Jacob Bar-Tana [Line breaks added] Abstract Post-acute SarS-Cov2 (PASC), Myalgia encephalomyelitis/Chronic fatigue syndrome (ME/CFS) and Post-acute infection syndrome (PAIS) consist of chronic post–acute infectious...
  4. forestglip

    mTOR inhibition improves immune function in the elderly, 2014, Mannick et al

    mTOR inhibition improves immune function in the elderly Joan B. Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M. Valiante, Jens Praestgaard, Baisong Huang, Michael A. Lonetto, Holden T. Maecker, John Kovarik, Simon Carson, David J. Glass, Lloyd B. Klickstein Abstract Inhibition of...
  5. SNT Gatchaman

    Preprint From Data to Insights: Machine Learning Empowers Prognostic Biomarker Prediction in Autism, 2023, Mehmetbeyoglu et al.

    From Data to Insights: Machine Learning Empowers Prognostic Biomarker Prediction in Autism Ecmel Mehmetbeyoglu; Abdulkerim Duman; Serpil Taheri; Yusuf Ozkul; Minoo Rassoulzadegan Autism Spectrum Disorder (ASD) poses significant challenges to society and science due to its impact on...
  6. B

    Rapamycin Pilot Treatment Trial for ME/CFS

    https://www.simmaronresearch.com/rapamycin-trial The First Biomarker-Driven Treatment Trial for ME/CFS Subsets Mean Success Until now, the heterogeneity of the patient population and the lack of a reliable biomarker to diagnose and prognose ME/CFS has thwarted clinical trials for both...
  7. SNT Gatchaman

    Hypothesis The Case for the Target of Rapamycin Pathway as a Candidate Circadian Oscillator, 2023, Lakin-Thomas

    The Case for the Target of Rapamycin Pathway as a Candidate Circadian Oscillator Lakin-Thomas, Patricia The molecular mechanisms that drive circadian (24 h) rhythmicity have been investigated for many decades, but we still do not have a complete picture of eukaryotic circadian systems. Although...
  8. SNT Gatchaman

    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy, 2023, Southwell et al.

    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy Nneka Southwell; Guido Primiano; Viraj Nadkarni; Nabeel Attarwala; Emelie Beattie; Dawson Miller; Sumaitaah Alam; Irene Liparulo; Yevgeniya I Shurubor; Maria Lucia Valentino; Valerio Carelli; Serenella...
    • SNT Gatchaman
    • Thread
    • amino acids atf4 fatty acid metabolism fatty acid oxidation fgf21 gdf15 integrated stress response lipid droplets lipid metabolism lipids metabolism mitochondria mtor muscle myopathy tca cycle
    • Replies: 4
    • Forum: Other health news and research
  9. SNT Gatchaman

    Preprint Thermosensitivity of translation underlies the mammalian nocturnal-diurnal switch, 2023, Beale et al.

    Thermosensitivity of translation underlies the mammalian nocturnal-diurnal switch Andrew David Beale; Nina M Rzechorzek; Andrei Mihut; Aiwei Zeng; Nicola J Smyllie; Violetta Pilorz; Rose Richardson; Mads F Bertlesen; Nathan R James; Shaline V Fazal; Zanna Voysey; Jerry Pelletier; Priya Crosby...
  10. belbyr

    mTOR activation, ATG13 inactivation and suppression of autophagy

    Split from USA: NIH National Institutes of Health news Avik Roy and Gunnar Gottschalk presented their hypothesis on a NIH ME/CFS working Group call A relevant paper is Elevated ATG13 in serum of pwME stimulates oxidative stress response in microglial cells , 2022, Gottschalk et al...
  11. SNT Gatchaman

    Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota: 2022, Li et al

    Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota Yunke Li, Ning Liu, Yao Ge, Ying Yang, Fazheng Ren, Zhenlong Wu Abstract The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both...
  12. SNT Gatchaman

    Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy, Puente et al, 2016

    Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy Cindy Puente, Ronald C Hendrickson, Xuejun Jiang Abstract Autophagy is a conserved catabolic process that utilizes a defined series of membrane trafficking events to generate a de novo double-membrane vesicle...
  13. Andy

    Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses.., 2021, Gabriel et al

    Full title: Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection Highlights Tpex cells preserve mitochondrial fitness during chronic infection TGF-β-mediated mTOR-inhibition preserves metabolism in Tpex...
  14. Hutan

    Ross River virus immune evasion strategies and the relevance to Post-Viral Fatigue, and ME onset, 2021, Lidbury

    https://www.frontiersin.org/articles/10.3389/fmed.2021.662513/abstract (provisionally accepted - article will be published soon) Brett A. Lidbury Research School of Population Health, Australian National University, Australia In Frontiers of Medicine - Infectious Diseases - Surveillance...
    • Hutan
    • Thread
    • lidbury me/cfs mtor ross river fever ross river virus
    • Replies: 4
    • Forum: ME/CFS research
  15. J

    Mitochondrial protein interaction landscape of SS-31, 2020, Chavez et al.

    https://www.pnas.org/content/early/2020/06/16/2002250117 popular article here https://newsroom.uw.edu/news/study-yields-clues-how-drug-may-boost-aged-mitochondria
  16. Sly Saint

    Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Missailidis et al Feb 2020

    https://www.preprints.org/manuscript/202002.0029/v1
    • Sly Saint
    • Thread
    • australia biomarker blood fisher lymphocytes me/cfs missailidis mitochondria mtor
    • Replies: 26
    • Forum: ME/CFS research
  17. Andy

    Sestrins are evolutionarily conserved mediators of exercise benefits, 2020, Kim et al

    In animal models. Open access, https://www.nature.com/articles/s41467-019-13442-5 Article. https://neurosciencenews.com/exercise-replacement-15458/
  18. John Mac

    An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients Missailidis et al. 2019

    https://www.preprints.org/manuscript/201909.0043/v1
    • John Mac
    • Thread
    • atp complex v fisher lymphoblasts me/cfs missailidis mitochondria mtor seahorse
    • Replies: 69
    • Forum: ME/CFS research
  19. NelliePledge

    Stanford Community Symposium 2018: Phair, Metabolic traps, Tryptophan trap

    This thread has been split from the main Stanford Community Symposium 2018 thread. Interesting presentation on metabolic traps focussing on tryptophan/kyneurenine. Serotonin And a very clear and strong message from Ron Davis that people should not experiment on themselves because he said...
  20. S

    Rapamune / Rapamycin/ mTOR

    Discovered on Easter Island, rapamycin has a unique history and impacts the mTOR pathways in our bodies. mTOR is like a general contractor in sensing nutrients and regulating homeostasis in all cells. The chat touches on ME-related things like how mTOR senses ATP, keto diets, methionine...
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