metformin

Abstract: Objectives Exercise capacity is decreased in diabetes mellitus due to impaired insulin sensitivity, endothelial dysfunction and mitochondrial dysfunction. The aim of the study was to evaluate the effect of metformin on exercise capacity in treatment naïve patients with type 2 diabetes...

Hello I have been working on an ME Hypothesis for the last few years. It describes three types of noradrenergic neuron dysfunction, two of which are mediated by insulin. Of course, there could be more subtypes not suggested in this hypothesis. I have made a video explaining the hypothesis-...

Given this recommendation for the use of metformin for people with Post Covid Condition who get a new Covid-19 infection, I thought it was worth having a discussion thread for it in the Treatment section. Relevant research threads can be found by clicking on the metformin tag, top left.

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID Vishnu Shankar; Julie Wilhelmy; Basil Michael; Layla Cervantes; Vamsee Mallajosyula; Ronald Davis; Michael Snyder; Shady Younis; William H Robinson; Sadasivan Shankar; Paul Mischel; Hector Bonilla; Mark Davis More than 65...

SARS-CoV-2 infection causes dopaminergic neuron senescence Liuliu Yang; Tae Wan Kim; Yuling Han; Manoj S. Nair; Oliver Harschnitz; Jiajun Zhu; Pengfei Wang; So Yeon Koo; Lauretta A. Lacko; Vasuretha Chandar; Yaron Bram; Tuo Zhang; Wei Zhang; Feng He; Chendong Pan; Junjie Wu; Yaoxing Huang; Todd...

"We found that metformin-treated individuals had less type-I myofiber atrophy during disuse, reduced pro-inflammatory transcriptional profiles, and lower muscle collagen deposition during recovery. Collagen content and myofiber size corresponded to reduced whole muscle cellular senescence and...

Metformin reduces SARS-CoV-2 in a Phase 3 Randomized Placebo Controlled Clinical Trial Carolyn T Bramante; Kenneth B Beckman; Tanvi Mehta; Amy B Krager; David J Odde; Christopher J Tignanelli; John B Buse; Darnell M Johnson; Ray H B Watson; Jerry J Daniel; David M Liebovitz; Jacinda M Nicklas...

https://www.nytimes.com/2023/03/14/well/marlena-fejzo-hyperemesis-gravidarum.html?unlocked_article_code=i7exBjGLMkMQVJKOgEZ_PBv29j4GYrj4q6R0YqeSGQumAtqyVKkXwLaZ7KLVZGykBQcxBasbEjYPcILSMlSxNDlw_xrprtr7hB0f7w_NpdqRTRX0ASFJqoJE3nbD1s1ehkYpzQPzcFMspQHlhOMLG0wwGtq1IVxqeaiDdNQ3_Of5T64T45gIEO70aUzvW5kwN...

Edit: Paper now published Post with abstract here. Outpatient Treatment of COVID-19 and the Development of Long COVID Over 10 Months: A Multi-Center, Quadruple-Blind, Parallel Group Randomized Phase 3 Trial Link (Open access to full paper) ************** Preprint abstract Outpatient...

Full title: β-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells Paywall, https://link.springer.com/article/10.1007/s10974-019-09568-0 Scihub, https://sci-hub.se/10.1007/s10974-019-09568-0

https://www.sciencedirect.com/science/article/pii/S0306987719309831

Posting for general interest as some patients report taking metformin. Paywall, https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.1548 Sci hub, https://sci-hub.se/10.1002/biof.1548

This is of interest because it is reporting amazing results (it is however a rather preliminary study). https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216079

An interesting correlation between use of these medications and reduced symptoms in a large scale study. One proposed mechanism is a reduction in inflammation. Neuroscience News : https://neurosciencenews.com/statins-mental-health-10473/ SMC reaction ...

I'm a skinny type 2 diabetic. Diagnosed 1997 but could have had it well before then. ME since 2011. Prior to ME I successfully controlled my diabetes with diet and exercise. With ME I was put on drugs. I had problems with Metformin - gut and energy - so I have been trying to manage without it...