lyme

New antibiotic offers hope for more effective Lyme disease treatment

Saw this posted from Science Translational Medicine (a reputable journal), and thought it looked exciting. I also note liver involvement - there are some reports of liver issues in some people with ME… Interested to know what people think. Abstract Persistent symptoms after an acute infection...

Abstract Background/Objectives: Although eligibility criteria for clinical trials significantly impact study outcomes, these criteria are often established without scientific justification, leading to delayed recruitment, small sample sizes, and limited study generalizability. Persistent Lyme...

A Wiltshire man has described "the brutal, brutal environment" he's dealing with during an Atlantic rowing challenge. John Watling, from Lacock, is part of a team attempting what's been dubbed ‘the world's toughest row’ - from the Canaries to Antigua... ...The team is raising money for Lyme...

ME/CFS and LC are discussed along with Lyme, as well as PEM. https://www.lymedisease.org/complexities-long-haul/

Abstract Introduction Diagnosing Borrelia miyamotoi disease (BMD) presents challenges due to its overlap with Lyme disease (LD) symptoms and the lack of reliable laboratory diagnostics. This case study demonstrates the successful use of phage-based PCR (phb-PCR) in identifying B. miyamotoi in...

Another PET TSPO neuroimaging study suggesting neuroinflammation involving microglia, this time in PTLDS: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1381-4

Abstract Innate immunity, the first line of defense against pathogens, relies on efficient elimination of invading agents by phagocytes. In the co-evolution of host and pathogen, pathogens developed mechanisms to dampen and evade phagocytic clearance. Here, we report that bacterial pathogens...

Summary Background Patients treated for Lyme borreliosis (LB) frequently report persistent symptoms. Little is known about risk factors and etiology. Methods In a prospective observational cohort study with a follow-up of one year, we assessed a range of microbiological, immunological, genetic...

The study: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011243 Findings as summarized in Time: https://time.com/6310027/lyme-disease-genes-severe-disease/? My summary: How sick you get depends on the strain (vs species) of Lyme you're infected with. It's not a...

https://www.pressherald.com/2023/08/31/commentary-the-pandemic-that-coronavirus-uncovered/ (Possibly promoting the writers 'blood test' to identify Lyme or LC.)

Independent: Clinics ‘cash in’ by wrongly diagnosing disease Justin Bieber suffers from (Lyme) https://www.independent.co.uk/news/uk/home-news/bieber-bella-hadid-lyme-disease-symptoms-b2400985.html

NIH awards will fund Post-Treatment Lyme Disease Syndrome research | National Institutes of Health (NIH)

Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: A Workshop to Examine Common, Overlapping Clinical and Biological Factors The National Academies of Sciences, Engineering, and Medicine The two-day event will be held June 29 and 30 in Washington DC. You can also attend...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00375-5 Highlights • RNA-seq of PBMCs from 152 individuals with post-treatment Lyme disease • Differential expression between acute, post-treatment, and uninfected • Machine learning to identify most relevant genes • 35 genes...

Protein biomarker profiles in serum and CSF in 158 patients with PTLDS or persistent symptoms after presumed tick-bite exposure compared to those in patients with confirmed acute neuroborreliosis Abstract Background Current diagnostics for patients with lingering symptoms categorized as...

Laboratory diagnosis of Lyme borreliosis: Current state of the art and future perspectives Lohr, B., Fingerle, V., Norris, D. E., & Hunfeld, K.-P. Abstract This review is directed at physicians and laboratory personnel in private practice and clinics who treat and diagnose Lyme borreliosis...

Abstract Background Media coverage of Lyme disease (LD) has led to an increase in consultations for presumed LD in Europe. However, LD is confirmed in only 10%–20% of patients, with a significant number remaining in a diagnostic dead-end. Objectives To reach a deeper understanding of how...

https://bjgplife.com/delicate-diagnosis-avoiding-harms-in-difficult-disputed-and-desired-diagnoses/ BJGP LONG READ ‘Delicate diagnosis’: avoiding harms in difficult, disputed, and desired diagnoses 7 October 2022 Margaret McCartney is an Honorary Senior Lecturer at the School of Medicine...

Abstract Previous studies have shown that monocytes can be ‘trained’ or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was found to be important in inducing this phenotype. As we previously found that Borrelia burgdorferi...