lactate

Lactate is a glycolysis product that is produced from pyruvate by LDH (lactate dehydrogenase) and plays an important role in physiological and pathological processes. However, whether lactate regulates autophagy is still unknown. We recently reported that LDHA is phosphorylated at serine 196 by...

Decreased physical performance despite objective and subjective maximal exhaustion in post-COVID-19 individuals with fatigue Vollrath, Shirin; Matits, Lynn; Schellenberg, Jana; Kirsten, Johannes; Steinacker, Jürgen M.; Bizjak, Daniel A. Introduction Fatigue is a common symptom in post-COVID-19...

Metabolic regulation of gene expression by histone lactylation Zhang, Di; Tang, Zhanyun; Huang, He; Zhou, Guolin; Cui, Chang; Weng, Yejing; Liu, Wenchao; Kim, Sunjoo; Lee, Sangkyu; Perez-Neut, Mathew; Ding, Jun; Czyz, Daniel; Hu, Rong; Ye, Zhen; He, Maomao; Zheng, Y. George; Shuman, Howard A...

Lactic acid in macrophage polarization: The significant role in inflammation and cancer Hai-cun Zhou; Xin-yan Yan ; Wen-wen Yu; Xiao-qin Liang; Xiao-yan Du; Zhi-chang Liu; Jian-ping Long; Guang-hui Zhao; Hong-bin Liu Metabolite lactic acid has always been regarded as a metabolic by-product...

Neurovascular coupling is the concept that in the CNS, organ function is tightly associated with blood flow, moreso than in other organs. Theoretical background and latest thinking — From the introduction in The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in...

Abstract Lactate shuttled from the blood circulation, astrocytes, oligodendrocytes or even activated microglia (resident macrophages) to neurons has been hypothesized to represent a major source of pyruvate compared to what is normally produced endogenously by neuronal glucose metabolism...

The mechanism of Long Covid (Post-Acute Sequelae of COVID-19; PASC) is currently unknown, with no validated diagnostics or therapeutics. SARS-CoV-2 can cause disseminated infections that result in multi-system tissue damage, dysregulated inflammation, and cellular metabolic disruptions. The...

Measuring extracellular human brain pH and amino acid metabolism with hyperpolarized [1-13C]pyruvate Alixander S Khan; Mary A McLean; Joshua D Kaggie; Ines Horvat-Menih; Tomasz Matys; Rolf F Schulte; Matthew Locke; Ashley Grimmer; Pascal Wodtke; Elizabeth Latimer; Amy Frary; Martin J Graves...

Nuclear Magnetic Resonance Spectroscopy Metabolomics in Idiopathic Intracranial Hypertension to Identify Markers of Disease and Headache Grech O, Seneviratne SY, Alimajstorovic Z, Yiangou A, Mitchell JL, Smith TB, Mollan SP, Lavery GG, Ludwig C, Sinclair AJ Background and objective: We...

Abstract Previous studies have shown that monocytes can be ‘trained’ or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was found to be important in inducing this phenotype. As we previously found that Borrelia burgdorferi...

Abstract Purpose: Previous studies in chronic fatigue syndrome (CFS) have reported reductions in maximal oxygen uptake (VO(2max)), yet often the testing procedures have not followed accepted guidelines, and gender data have been pooled. The present study was undertaken to reevaluate exercise...

Lactate: the ugly duckling of energy metabolism Rabinowitz JD, Enerbäck S Lactate, perhaps the best-known metabolic waste product, was first isolated from sour milk, in which it is produced by lactobacilli. Whereas microbes also generate other fermentation products, such as ethanol or acetone...

To the Editor: After acute infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many individuals experience a range of symptoms including dyspnea, exercise intolerance, and chest pain commonly referred to as “post–COVID-19 syndrome” or as post-acute sequelae of...

Abstract The human large intestinal microbiota thrives on dietary carbohydrates that are converted to a range of fermentation products. Short-chain fatty acids (acetate, propionate and butyrate) are the dominant fermentation acids that accumulate to high concentrations in the colon and they...

0.91 mmol/L with a reference range of 0.9 to 1.7 Technically not yet low, but close enough. Is this a suspicious result? Aren't people with ME/CFS supposed to tend towards increased lactate levels?

NEW & NOTEWORTHY During exercise the brain consumes lactate as a substitute for glucose. Propranolol has previously attenuated this cerebral lactate uptake, suggesting a β-adrenergic transport mechanism. However, in the present study, we demonstrate that the fractional extraction of arterial...

An ad is currently being circulated in Swedish ME groups on social media, a research study led by prof Jonas Bergquist at Uppsala University that is currently recruiting. It's a study on altered energy metabolism in ME/CFS, focusing mainly on lactate, glucose and hypoxanthine. (I couldn't find...

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and debilitating disease accompanied by muscular fatigue and pain. A functional measure to assess muscle fatigability of ME/CFS patients is, however, not established in clinical routine. The aim of this...

Open access, https://www.tandfonline.com/doi/full/10.1080/19390211.2020.1796885

Abstract Chronic fatigue syndrome (CFS) is a complex illness, which is often misdiagnosed as a psychiatric illness. In two previous reports, using 1H MRSI, we found significantly higher levels of ventricular cerebrospinal fluid (CSF) lactate in patients with CFS relative to those with...