https://www.tandfonline.com/doi/abs/10.1080/21641846.2025.2483112
Research Article
Caffeine against persistent fatigue in long-COVID: a randomized clinical trial
Liziane Rosa Cardoso
Maria Cristine Campos
Tatyana Nery
Ana Cristina de Bem Alves
Ana Elisa Speck
Naiara Souza dos Santos
Izabel...
Assessing Neuroinflammation in GWI Using MRS
Sponsor: University of Alabama at Birmingham
Principal Investigator: Jarred Younger
Study Description
This proposal is for a Tier 1 (Discovery) study that uses a human, cross-sectional, observational neuroimaging approach to measure...
Journal reference:
Leija, R. G., et al. (2024). Enteric and systemic postprandial lactate shuttle phases and dietary carbohydrate carbon flow in humans. Nature Metabolism. doi.org/10.1038/s42255-024-00993-1.
Lactate is essential to buffering the effects of a carbohydrate meal, study shows (msn.com)
[In mice]
Abstract
Several metabolites have been shown to have independent and at times unexpected biological effects outside of their metabolic pathways. These include succinate, lactate, fumarate, and 2-hydroxyglutarate. 2-Hydroxybutyrate (2HB) is a byproduct of endogenous cysteine...
miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses
Paola Pinto-Hernandez; Manuel Fernandez-Sanjurjo; Daan Paget; Xurde M Caravia; David Roiz-Valle; Juan Castilla-Silgado; Sergio Diez-Robles; Almudena Coto-Vilcapoma; Pau Gama; Pablo M Garcia-Roves...
Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder
Lingampelly, Sai Sachin; Naviaux, Jane C.; Heuer, Luke S.; Monk, Jonathan M.; Li, Kefeng; Wang, Lin; Haapanen, Lori; Kelland, Chelsea A.; Van de Water, Judy; Naviaux, Robert K.
Classical...
Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence
Juan José Oropeza-Valdez; Cristian Padron-Manrique; Aaron Vazquez-Jimenez; Xavier Soberon-Mainero; Osbaldo Resendis-Antonio
The COVID-19 pandemic, caused by...
Highlights
Lactate monitoring has the potential to extend beyond applied sports settings and could be used to monitor the physiologic and pathophysiological responses to external and internal stimuli in chronic disease areas such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)...
The use of muscle near-infrared spectroscopy NIRS to assess the aerobic training loads of world-class rowers
Andrzej Klusiewicz; Kinga Rębiś; Mariusz Ozimek; Adam Czaplicki
The objectives of this study were (1) to characterize the changes in oxygenation derived from muscle near-infrared...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393352/
Abstract
The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance...
Redefining the role of Hypoxia-inducible factors HIFs in oxygen homeostasis
Clemente Fernández Arias; Franciso J Acosta; Federica Bertocchini; Cristina Fernández-Arias
Hypoxia-inducible factors (HIFs) are key regulators of intracellular oxygen homeostasis. The marked increase in HIFs activity...
acetyl co a
glycolysis
hif-1
hypoxia
hypoxic stress
lactate
metabolix
oxidative phosphorylation
oxidative stress
pyruvate
reverse electron transport
warburg effect
Excessive Intracellular Acidosis Of Skeletal Muscle On Exercise In A Patient With A Post-Viral Exhaustion/Fatigue Syndrome: A 31P Nuclear Magnetic Resonance Study
Arnold; Radda; Bore; Styles; Taylor
A patient with prolonged post-viral exhaustion and excessive fatigue was examined by 31P nuclear...
Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T 1H MRS imaging study
Sanjay J. Mathew; Xiangling Mao; Kathryn A. Keegan; Susan M. Levine; Eric L. P. Smith; Linda A. Heier; Viktor Otcheretko; Jeremy D...
Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity
Vermeulen, Ruud CW; Kurk, Ruud M; Visser, Frans C; Sluiter, Wim; Scholte, Hans R
Background
The aim of this study was to investigate...
Introduction
Monitoring muscle metabolic activity via blood lactate is a useful tool for understanding the physiological response to a given exercise intensity. Recent indications suggest that skeletal muscle oxygen saturation (SmO2), an index of the balance between local O2 supply and demand...
Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV
Irini Sereti; Myrthe L. Verburgh; Jacob Gifford; Alice Lo; Anders Boyd; Eveline Verheij; Aswin Verhoeven; Ferdinand W.N.M. Wit; Maarten F. Schim van der Loeff; Martin Giera...
Abstract
It is well known that glucose serves as the main energy substrate for the brain, and emerging evidence emphasizes its involvement in both physiological processes and disease (traumatic brain injury, memory, epilepsy, etc.). Furthermore, the usefulness of mathematical modeling in...
Regional quantification of cardiac metabolism with hyperpolarized 1-13C-pyruvate MRI evaluated in an oral glucose challenge
Peder E. Z. Larson; Shuyu Tang; Xiaoxi Liu; Avantika Sinha; Nicholas Dwork; Sanjay Sivalokanathan; Jing Liu; Robert Bok; Karen G Ordovas; James Slater; Jeremy Gordon; Maria...
Peripheral measurements of venous oxygen saturation and lactate as a less invasive alternative for hemodynamic monitoring
Chemtob, Raphaelle Avigael; Møller-Sørensen, Hasse
Background
Peripheral measurement of venous oxygen saturation and lactate is a less invasive alternative to monitor tissue...
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