irg1

  1. Mij

    IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1, 2025, Li Chai et al

    Highlights IRG1-itaconic acid axis feedback inhibits TBK1-triggered type I IFN response Itaconic acid induces TBK1 alkylation at Cys605, disrupting its dimerization Development of ITA-5 and ITA-9 limit excess type I IFN-mediated hyperinflammation Summary Perturbation of energy metabolism is...
  2. Mij

    Itaconate modulates immune responses via inhibition of peroxiredoxin 5, 2025, Tomas Paulenda et al

    Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...
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    • interferon irg1 itaconate macrophages paulenda peroxiredoxin prdx2 prdx6 ros
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    • Forum: Other health news and research
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    Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation & cell metab,Chen 2022

    Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism https://www.nature.com/articles/s42255-022-00577-x Although the immunomodulatory and cytoprotective properties of itaconate have been studied...
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    Scientists discover promising ‘off-switch’ for inflammatory diseases

    https://www.irishtimes.com/news/health/scientists-discover-promising-off-switch-for-inflammatory-diseases-1.3443334?mode=amp
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