inflammation

Ageing is accompanied by declining memory function, with extremely heterogeneous manifestation in the human population. Brain-extrinsic factors influencing cognitive decline, such as gastrointestinal signals, have emerged as attractive targets for peripheral interventions but the underlying...

Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID Post COVID-19 condition (Long COVID, LC) is frequently accompanied by persistent neurological symptoms, but the mechanisms linking intestinal dysbiosis to neuroinflammation remain...

Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection Plasma proteomic profiling of 92 individuals with Post-Acute Sequelae of SARS-CoV-2 infection (PASC), assessed a mean of 34 months after acute infection, revealed a distinct...

Neuroinflammation: an unfortunate term to describe schizophrenia Abstract Schizophrenia, a chronic psychiatric disorder, has prompted extensive research into its immunological aspects. Studies in genetics, epidemiology, and treatment have revealed immune changes associated with schizophrenia...

Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is...

Highlights • IL-1β uniquely triggers self-imposed social withdrawal during inflammation • IL-1R1-positive DRN serotonergic neurons mediate social withdrawal • A peripheral-to-central IL-1β relay sustains prolonged social withdrawal Summary Sick animals exhibit behavioral changes that extend...

Persistent lung and vascular inflammation in mild to moderate COVID-19 survivors detected by ¹⁸F-FDG PET/CT: A quantitative imaging study with implications for cardiovascular risk PURPOSE Lingering inflammation after COVID-19 has been proposed as a contributor to long-term cardiovascular risk...

A Comparative Study of the Coagulation Systems and Inflammatory Profiles of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Patients with Long COVID Hayley Emma Arron Supervisor: Prof. Etheresia Pretorius Stellenbosch University [Line breaks added] Abstract Myalgic...

Muscle Abnormalities in Nonhospitalised Patients With Post–COVID-19 Condition BACKGROUND Post-COVID condition (PCC) affects ~10% of SARS-CoV-2–infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the...

Abstract Inherited deficiency of zinc finger NFX1-type containing 1 (ZNFX1), a dsRNA virus sensor, is associated with severe familial immunodeficiency, multisystem inflammatory disease, increased susceptibility to viruses, and early mortality. However, limited treatments for patients with...

Sex differences in inflammation and markers of gut integrity in long COVID Endothelial damage represents an essential pathogenic mechanism of respiratory and multiorgan dysfunction as seen in the post-acute phase of COVID-19. Biological differences between male and female sex, inflammation...

Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia following SARS-CoV-2 infection in long COVID-19 Bae, Gyuntae; Yang, Zhiqi; Bucci, Daniele; Wegner, Claire; Schäfer, Hartmut; Singh, Yogesh; Lonati, Caterina; Trautwein, Christoph...

Acute and Chronic Post-COVID-19 Conditions: A Study of Genetic Integrity and Clinical Markers Bruna Alves Alonso Martins, Ana Leticia Hilario Garcia, Malu Siqueira Borges, Daiane Dias Ribeiro Nobles, Alana Witt Hansen, Fernando Rosado Spilki, Lavínia Schuler-Faccini, Pabulo Henrique Rampelotto...

340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park Background As the number of COVID-19 survivors amongst the global population continues to rise, the...

Full title: Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 Rebeka Fekete, Alba Simats, Eduárd Bíró, Balázs Pósfai, Csaba Cserép, Anett D. Schwarcz, Eszter Szabadits, Zsuzsanna Környei, Krisztina...

The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination Maatz, Henrike; Lindberg, Eric L.; Adami, Eleonora; López-Anguita, Natalia; Perdomo-Sabogal, Alvaro; Cocera Ortega, Lucía; Patone, Giannino; Reichart...

iPSC-derived human cortical organoids display profound alterations of cellular homeostasis following SARS-CoV-2 infection and Spike protein exposure Gioia Cappelletti; Lorenzo Brambilla; Sergio Strizzi; Fiona Limanaqi; Valentina Melzi; Mafalda Rizzuti; Monica Nizzardo; Irma Saulle; Daria...

Now published - see here Preprint Identification of a multi-omics factor predictive of long COVID in the IMPACC study Gisela Gabernet; Jessica Maciuch; Jeremy P Gygi; John F Moore; Annmarie Hoch; Caitlin Syphurs; Tianyi Chu; Naresh Doni Jayavelu; David B Corry; Farrah Kheradmand; Lindsey R...

Molecular and Immunological Signatures of Long COVID: Implications for Diagnosis and Personalized Treatment Strategies Jorine K.N. Hammink, Tim R. van Elst [Line breaks added] Summary The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to an emerging health challenge known as “long...

Identifying Neuro-inflammatory Biomarkers of Generalized Anxiety Disorder from Lymphocyte Subsets based on machine learning approaches Jingjing Lu, Weiwei Liang, Lijun Cui, Shaoqi Mou, Xuedan Pei, Xinhua Shen, Zhongxia Shen, Ping Shen Introduction Activation of the inflammatory response system...