immunoglobulin

Mass-Standardised IgG Response to Fourteen SARS-CoV-2 Spike Protein variants and Antibody Subclass analysis for IgG subclasses and IgE for a Long COVID Patient Cohort A multivariant total subclass analysis has been performed for a control cohort (n=15) and a long COVID patient cohort (n=15)...

Robust antibody and T cell responses tracked longitudinally in patients with long COVID After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a minority of patients experience persistent or emerging symptoms, termed ‘long coronavirus disease (COVID) or post-acute...

Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia Fibromyalgia syndrome (FM) is characterized by widespread pain and fatigue. People living with FM also experience tactile allodynia, cold-evoked pain, paraesthesia and dysaesthesia. There is evidence of small...

Blood diagnostic biomarkers for neurologic manifestations of long COVID BACKGROUND SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, millions of deaths and ongoing manifestations post COVID-19. “Long Covid”, a Post-Acute Sequelae of COVID-19 (PASC), is...

Post-COVID syndrome patients show reduced anti-Spike antibodies compared to COVID-recovered controls, but enhanced IgG4/IgG1 switch after the third vaccine dose INTRODUCTION Long COVID and post-COVID syndromes represent a significant global health crisis and a substantial societal challenge...

Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis BACKGROUND AND OBJECTIVES Intrathecal synthesis of immunoglobulin G (IgG) is a key feature of multiple sclerosis (MS) and a prognostic marker for the disease course. Although previous...

Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID Long COVID (LC) is a post-acute infection syndrome affecting 5%–10% of individuals infected by SARS-CoV-2. Here, we aimed to study SARS-CoV-2 humoral immunity, immunological...

See post #27 for peer-reviewed version. Abstract: Autoimmunity is a key clinical feature in both post-infectious Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of COVID (PASC). Passive transfer of immunoglobulins from patients' sera into mice induces some...

Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children...

The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells Fibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanism...

Comprehensive molecular characterization of post-COVID condition: Immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers Seco-Gonzalez; Antelo-Riveiro; Bravo; Domínguez-Santalla; Rodríguez-Ruiz; Piñeiro; Garcia-Fandino BACKGROUND Post-COVID condition...

Protective role of anti-SARS-CoV-2 antibody responses against vital organ related long COVID symptoms Yukari Magawa, Jhosiene; Jacintho, Lucas Cauê; Alves Ferreira, Marcelo; Ramos Oliveira, Jamille; Rahal Guaragna Machado, Rafael; Kuramoto Takara, Andreia; Moreno Lima de Oliveira, Renata...

This is the abstract of the preprint. See post #3 for peer-reviewed paper. ------------------------------------------------------ Effect on Quality of Life of Therapeutic Plasmapheresis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Elevated β-Adrenergic and M3-Muscarinic...

SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole Petry; Shoykhet; Weiser; Griesbaum; Bashiri Dezfouli; Verschoor; Wollenberg COVID-19 patients face an increased risk of thromboembolic complications, yet the exact pathophysiological role of platelets...

Immunotherapies for Postural Orthostatic Tachycardia Syndrome, Other Common Autonomic Disorders and Long COVID: Current State and Future Direction Blitshteyn, S., Funez-dePagnier, G., Szombathy, A., & Hutchinson, M Abstract Postural orthostatic tachycardia syndrome (POTS), neurocardiogenic...

Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures Huanhuan Li; Minh C. Pham; Jinfeng Teng; Kevin C. O’Connor; Colleen M. Noviello; Ryan E. Hibbs Skeletal muscle contraction is triggered by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at...

Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19 Jiangfeng Liu; Li Guo; Jingchuan Zhong; Yue Wu; Xinming Wang; Xiaoyue Tang; Kaiyuan Min; Yehong Yang; Wanjun Peng; Qiaochu Wang; Tao Ding; Xiaoying...

Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies Cole Maguire; Kristina Kashyap; Elizabeth Williams; Aziz Rija; Maisey Schuler; Cheyenne Ahamed; Chumeng Wang; Aurelia Mena; Jeffrey Saniuk; Johanna Busch; Sara Austin; Mary Kelley...

Proteomics Reveals That Vitamin D Deficiency Leads to Immunoglobulin Abnormalities and Immune Dysregulation in Patients with Post-COVID-19 Condition Wenrui Ji; Xiaomin Xie; Guirong Bai; Yalei Fan; Yanting He; Li Zhang; Haiyan Zhou; Ling Li; Huan Li Vitamin D (VD) levels are closely related to...

ACE-2-like Enzymatic Activity in COVID-19 Convalescent Patients with Persistent Pulmonary Symptoms Associated with Immunoglobulin Yufeng Song; Frances Mehl; Lyndsey M. Muehling; Glenda Canderan; Kyle Enfield; Jie Sun; Michael Yin; Sarah J. Ratcliffe; Jeffrey M Wilson; Alexandra Kadl; Judith A...