Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine
Jolink; Feldman; Antenucci; Cardenas; West; Nakamura; Muscatell
The influenza vaccine has reliably been associated with mild, within-person increases in...
Meningeal lymphatics-microglia axis regulates synaptic physiology
Kyungdeok Kim; Daviti Abramishvili; Siling Du; Zachary Papadopoulos; Jay Cao; Jasmin Herz; Igor Smirnov; Jean-Leon Thomas; Marco Colonna; Jonathan Kipnis
SUMMARY
Meningeal lymphatics serve as an outlet for cerebrospinal fluid...
The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review
Thiago Henrique Teodoro, Katerine Palharini Manfrin Costa, Jonato Prestes, Jos Campanholi, James Navalta, Guilherme Borges Pereira
Purpose: Imbalance between Th1 and Th2 cells...
340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms
Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park
Background
As the number of COVID-19 survivors amongst the global population continues to rise, the...
Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults
Nicholas Donnelly, Ruby Tsang, Èimear M Foley, Holly Fraser, Aimee Hanson, Golam M Khandaker
Background
Depression is associated with alterations in immuno-metabolic biomarkers, but it remains...
Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures
Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer...
Seasonal variation in the associations between self-reported long-COVID symptoms and IL-6 signalling-related factors (particularly the rs2228145 variant of the IL-6R gene): A clinical study.
Katie Rees, Rebecca Aicheler, Lee Butcher, Alan Dodd, John Geen, Ceri Lynch, Isabel Massey, Keith...
Highlights
Mononuclear cells are primary drivers of the exercise response in skeletal muscle
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Release of histamine from skeletal muscle during exercise from mast cells
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Histamine receptor antagonists impair post-exercise muscle glycogen resynthesis
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Exercise-induced transcriptional...
Abstract:
The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been...
Association of inflammation cytokines with cognitive function in first-episode major depressive disorder
Yanfang Wang, Yanqing Xi, Zongqi Wang, Guojuan Li, Zhuoqun Hao, Jiahui Nie, Jinxiang Li, Yuting Tan, Xiaodong Hu, Genwei Wang, Sha Liu
[Provisionally accepted]
Abstract
Abnormal cognitive...
Abstract
Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown.
Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...
Effects of physical training on coagulation parameters, interleukin-6, and angiotensin-converting enzyme-2 in COVID-19 survivors
Binabaji, Soheila; Rahimi, Mohammad; Rajabi, Hamid; Keshavarz, Mohsen; Rahimi, Rahimeh; Ahmadi, Azam; Gahreman, Daniel
COVID-19 is a highly contagious virus that uses...
Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)
Anna Katharina Mundorf, Amelie Semmler, Harald Heidecke, Matthias Schott, Falk Steffen, Stefan Bittner, Karl J. Lackner, Karin Schulze-Bosse, Marc Pawlitzki, Sven Guenther Meuth, Frank Klawonn, Jana Ruhrländer...
Tocilizumab Reduces Hypercoagulation in COVID-19 - Perspectives from The Coagulation and Immunomodulation Covid Assessment Coag-ImmCovA Clinical Trial.
Lou M Almskog; Anna Sjostrom; Jonas Sunden-Cullberg; Apostolos Taxiarchis; Anna Agren; Sara Freyland; Madeleine Borjesson; Agneta Wikman; Carl...
Extreme γ′ fibrinogen levels in COVID-19 patients
Hudkins; Hamilton; Underwood; Kazmierczak; Dewey; Kazmierczak; Messer; Khan; Schreiber; Farrell
COVID-19 disease progression can be accompanied by a “cytokine storm” that leads to secondary sequelae such as acute respiratory distress syndrome...
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