SARS-CoV-2 Viral Load and Cytokine Dynamics Profile as Early Signatures of Long COVID Condition in Hospitalized Individuals
Jacobo Alonso Domínguez; Inés Martínez Barros; Irene Viéitez; Mercedes Peleteiro; Beatriz Calderón-Cruz; José A. González-Nóvoa; Alexandre Pérez González; Virginia Leiro...
Cytokines IL1β, IL6, TNFα and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19
Michael Fleischer; Fabian Szepanowski; Anne K Mausberg; Livia Asan; Ellen Uslar; Denise Zwanziger; Lothar Volbracht; Mark Stettner; Christoph...
Inflammatory Cytokines Can Induce Synthesis Of Type-I Interferon
Nikhil Sharma; Xu Qi; Patricia Kessler; Ganes C. Sen
Type I interferon (IFN) is induced in virus infected cells, secreted and it inhibits viral replication in neighboring cells. IFN is also an important player in many non-viral...
Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease
One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...
Exosome-associated Mitochondrial DNA is Elevated in Patients with ME/CFS and Stimulates Human Cultured Microglia to Secrete IL-1β
https://www.researchsquare.com/article/rs-154011/v1
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease that presents...
Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1β
Abstract
Abstract. Nijs J, Van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Frémont M, Paul L (Vrije Universiteit Brussel...
[This seems to be only very tenuously about ME/CFS]
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown etiology and without effective treatment options. The onset of ME/CFS is often associated with neuroinflammation following bacterial or...
The article, https://medicalxpress.com/news/2018-05-breakthrough-bioelectronic-medicine-discovery-decoding.amp
The paper, http://www.pnas.org/content/early/2018/05/02/1719083115
A way to measure cytokine levels in vivo using essentially a biologically coated optical fibre guided into the brain via a stereotactically positioned guide cannula.
Potentially of interest for real-time monitoring in ME if cytokines in the brain are relevant...
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