hypoxia

Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights August Hoel; Fredrik Hoel; Sissel Elisabeth Furesund Dyrstad; Henrique Chapola; Ingrid Gurvin Rekeland; Kristin Risa; Kine Alme; Kari Sorland; Karl Albert Brokstad; Hans-Peter Marti; Olav Mella; Oystein...

Post-COVID microvascular dysfunction in hospitalized COVID-19 survivors is associated with acute disease severity and persistent cognitive complaints Noa van der Knaap; Simona Klinkhammer; Alida A. Postma; Johanna M.A. Visser-Meily; Janneke Horn; Caroline M. van Heugten; Paulien H.M. Voorter...

Rhodoquinone carries electrons in the mammalian electron transport chain Jonathan Valeros et 31 al. Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal electron acceptor oxygen (O2). In hypoxia...

Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19 Adingupu, Damilola D.; Soroush, Ateyeh; Hansen, Ayden; Twomey, Rosie; Dunn, Jeff F. OBJECTIVES Systemic hypoxia occurs in COVID-19 infection; however, it is unknown if cerebral hypoxia occurs in convalescent...

Redefining the role of Hypoxia-inducible factors HIFs in oxygen homeostasis Clemente Fernández Arias; Franciso J Acosta; Federica Bertocchini; Cristina Fernández-Arias Hypoxia-inducible factors (HIFs) are key regulators of intracellular oxygen homeostasis. The marked increase in HIFs activity...

Full title: Coenzyme Q deficiency in endothelial mitochondria caused by hypoxia; remodeling of the respiratory chain and sensitivity to anoxia/reoxygenation Highlights In endothelial cells, hypoxia reduces HMGCR levels via HIF1α, leading to Q deficiency. The hypoxia-induced increased level...

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III Brandon Chen; Theophilus M Lynn-Nguyen; Pankaj Jadhav; Benjamin S Halligan; Nicholas J Rossiter; Rachel M Guerra; Sergei Koshkin; Imhoi Koo; Pietro Morlacchi...

Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments Jeremy B. Ducharme ; Zachary J. McKenna ; Jonathan W. Specht ; Zachary J. Fennel ; Quint N. Berkemeier ; Michael R. Deyhle Exercise...

Circulating Metabolome and White Matter Hyperintensities in Women and Men Eeva Sliz; Jean Shin; Shahzad Ahmad; Dylan M. Williams; Stefan Frenzel; Friederike Gauß; Sarah E. Harris; Ann-Kristin Henning; Maria Valdes Hernandez; Yi-Han Hu; Beatriz Jiménez; Muralidharan Sargurupremraj; Carole Sudre...

Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome PACS “long COVID” Adingupu, Damilola D.; Soroush, A.; Hansen, A.; Twomey, R.; Dunn, J. F. There is evidence that hypoxia occurs in the brain of some individuals who contracted the COVID-19 disease. Furthermore...

Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach Background: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact...

This study found reduced oxygen extraction in the thigh muscles of people with ongoing symptoms after Covid-19 infections as compared to healthy controls: Structural and functional impairments of skeletal muscle in patients with [PASC], 2023, Colosio et al. The measure is "Δ[HHbMb]peak (%...

The Role of the Hypoxia-Related Unfolded Protein Response UPR in the Tumor Microenvironment Bartoszewska, Sylwia; Collawn, James F.; Bartoszewski, Rafal Despite our understanding of the unfolded protein response (UPR) pathways, the crosstalk between the UPR and the complex signaling networks...

Role of miR-2392 in driving SARS-CoV-2 infection J. Tyson McDonald; Francisco J. Enguita; Deanne Taylor; Robert J. Griffin; Waldemar Priebe; Mark R. Emmett; Mohammad M. Sajadi; Anthony D. Harris; Jean Clement; Joseph M. Dybas; Nukhet Aykin-Burns; Joseph W. Guarnieri; Larry N. Singh; Peter...

Mitochondria and oxygen homeostasis Mateus P. Mori; Rozhin Penjweini; Jay R. Knutson; Ping-yuan Wang; Paul M. Hwang Molecular oxygen possesses a dual nature due to its highly reactive free radical property: it is capable of oxidizing metabolic substrates to generate cellular energy, but can...

Highlights Hypoxia inducible factors – mitochondria crosstalk underlies adaptations to hypoxia. Controlled induction of hypoxia responses yields potent health benefits. Environmental and behavioral conditions modulate adaptations to hypoxia. Understanding the determinants of adaptation...

Hypoxia activates the unfolded protein response signaling network: An adaptive mechanism for endometriosis Zhou, Yong; Jin, Yang; Wang, Yuan; Wu, Ruijin Endometriosis (EMS) is a chronic gynecological disease that affects women of childbearing age. However, the exact cause remains unclear. The...

For published version see Altered tissue oxygenation in patients with post COVID-19 syndrome (2023, Microvascular Research) ******************** Pre-Print https://www.researchgate.net/publication/369239099_Altered_Tissue_Oxygenation_in_Patients_with_Post_COVID-19_Syndrome Background: Post...

Abstract Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development of animal models that recapitulate the neuropathological findings of autopsied brain tissue from patients who died from...

Full title: CFS/ME, FM: “THERAPEUTIC TEST” AND FIRST TREATMENT SCHEME FOR PATIENTS WITH CHRONIC FATIGUE AND BRAIN FOG TO ASSIST THE DIAGNOSIS OF PERSISTENT CLOTS AND HYPOPERFUSION. For patients with Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Fibromyalgia, Persistent Symptoms of COVID...