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  1. C

    GRADE methodology: BMJ Rapid Response, Nunan, 2024

    Rapid Response: Re: Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses Dear Editor A pervasive issue in health research is overlooking uncertainty in interpreting findings. Lane et al employ the GRADE methodology, which is designed to...
  2. Jonathan Edwards

    Who Agrees That GRADE is (a) unjustified in theory and (b) wrong in practice?

    The idea of GRADE to provide a recipe for making decisions for people who are not themselves capable of making such decisions on their own is a flawed and dangerously counterproductive idea in a medical context. The pseudo-arithmetic structure of allocating evidence to 'grades' has no purpose...
  3. Sasha

    Circulating leptin levels in patients with [ME], [CFS] or fibromyalgia a systematic review protocol, 2020, Musker et al

    Several related threads have been merged. Link to the research protocol for the literature review here. Story in the Australian news: SAHMRI researchers in hunt to find cure for Chronic Fatigue Syndrome WORLD-first research in Adelaide that involves taking the blood samples of donors every...
  4. ME/CFS Skeptic

    My comments to the Cochrane review

    I plan to submit these comments to the current version of the Cochrane review next week (sorry I took me so long to write these down - long story). I thought it might be useful to post it here on S4ME first in case someone notices any mistakes so that I can still correct these before formally...
  5. Sly Saint

    Assessing Randomised Controlled Trials

    There are a number of tools available for journals to use to help assess RCTs. I wondered if anyone here had 'tried them out' for PACE and/or any of the other 'RCT's by Crawley or Chalder? I've seen CASP mentioned...
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