glutamate

AMPA receptors in the synapse: Very little space and even less time Jelena Baranovic Glutamate is by far the most abundant neurotransmitter used by excitatory synapses in the vertebrate central nervous system. Once released into the synaptic cleft, it depolarises the postsynaptic membrane and...

Systemic increase of AMPA receptors associated with cognitive impairment of long COVID Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and...

Long term effect of COVID-19 on brain metabolism and connectivity Beatrice Bravi; Marco Paolini; Federica Colombo; Mariagrazia Palladini; Valentina Bettonagli; Mario Gennaro Mazza; Rebecca De Lorenzo; Patrizia Rovere-Querini; Francesco Benedetti; Sara Poletti AIMS After 3 years from the...

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis Sai Zhang; Fereshteh Jahanbani; Varuna Chander; Martin Kjellberg; Menghui Liu; Katherine Glass; David Iu; Faraz Ahmed; Han Li; Rajan Douglas Maynard; Tristan Chou...

New insights into how glutamate opens brain cell signaling channels eta: Journal reference: Mondal, A. K., et al. (2025). Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. Nature. doi.org/10.1038/s41586-025-08770-0.

Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption Chaganti, Joga R.; Talekar, Tanush K.; Brew, Bruce James BACKGROUND AND PURPOSE The glymphatic system, a waste clearance pathway, has been implicated in several...

Neurometabolic network NMetNet for functional neurological disorder in children and adolescents Lan; Foster; Charney; Grinsven; Breedlove; Kozlowska; Lin OBJECTIVES Functional neurological disorder (FND) in children and adolescents is a biopsychosocially-complex condition characterized by a...

Delayed-Onset Muscle Soreness Begins with a Transient Neural Switch Sonkodi, Balázs Unaccustomed and/or strenuous eccentric contractions are known to cause delayed-onset muscle soreness. In spite of this fact, their exact cause and mechanism have been unknown for more than 120 years. The...

Longitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6–36 months after COVID-19 Yang, Huqin; Guan, Lujia; Xue, Yi; Li, Xuyan; Gao, Leyi; Zhang, Zhijin; Zhang, Haifan; Ma, Haomiao; Liu, Fengjiao; Huang, Xuan; Tong, Zhaohui; Li, Jieqiong Approximately 10–30% of...

Abstract: We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not...

Exertional Exhaustion Post-Exertional Malaise, PEM Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Baraniuk, James N. Post-exertional malaise (PEM) is a defining condition of myalgic...

Epigenetic patterns, accelerated biological aging, and enhanced epigenetic: drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study, 2024, Calzari Luciano, Dragani Davide Fernando et al Abstract Background The epigenetic status of patients 6-month...

Insights into COVID-19 pathophysiology from a longitudinal multisystem report during acute infection Brihmat; Bayram; Bheemreddy; Saleh; Yue; Forrest The Coronavirus disease 2019 (COVID-19), an illness caused by a SARS-CoV-2 viral infection, has been associated with neurological and...

Open access https://journals.sagepub.com/doi/10.1177/0271678X241270528 Research article First published online August 7, 2024 Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI Laura Schönberg, Abdalla Z Mohamed, Qiang Yu, Richard A Kwiatek, Peter Del Fante...

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the highly contagious respiratory disease Corona Virus Disease 2019 (COVID-19) that may lead to various neurological and psychological disorders that can be acute, lasting days to weeks or months...

Blood brain barrier disruption and glutamatergic excitotoxicity in post-acute sequelae of SARS COV-2 infection cognitive impairment: potential biomarkers and a window into pathogenesis Chaganti, Joga; Poudel, Govinda; Cysique, Lucette Adeline; Dore, Gregory J.; Kelleher, Anthony; Matthews, Gael...

https://www.sciencedirect.com/science/article/pii/S000293432400216X Imbalanced Brain Neurochemicals in long COVID and ME/CFS: A Preliminary Study using MRI Kiran Thapaliya, PhD 1*, Sonya Marshall-Gradisnik, PhD 1 , Natalie Eaton-Fitch, PhD 1 , Zeinab Eftekhari BSc (Honours)2 ,Maira Inderyas...

Polysomnography has shown that I have Periodic Limb Movement Disorder (PLMD). I also tick all boxes for RLS (and never been diagnosed with fibromyalgia). I can't describe how happy I was to see, written in black and white, numerically quantified, accompanied by "obviously [patient] has PLMD that...

Metabolic Fingerprinting for the Diagnosis of Clinically Similar Long COVID and Fibromyalgia Using a Portable FT-MIR Spectroscopic Combined with Chemometrics Hackshaw, Kevin V.; Yao, Siyu; Bao, Haona; de Lamo Castellvi, Silvia; Aziz, Rija; Nuguri, Shreya Madhav; Yu, Lianbo; Osuna-Diaz, Michelle...

Brain fog in long COVID: A glutamatergic hypothesis with astrocyte dysfunction accounting for brain PET glucose hypometabolism Abstract Brain [18F]FDG-PET scans have revealed a glucose hypometabolic pattern in patients with long COVID. This hypometabolism might reflect primary astrocyte...