fibrinogen

IgA autoimmunity and coagulation among post-acute sequelae of SARS-CoV-2 infection (PASC) patients with persistent respiratory symptoms: a case-control study Claudia Gomes, Jonathan H. Whiteson, Fabio Ponzo, Rany Condos, Mila B. Ortigoza, Marisol Zuniga, Ana Rodriguez, David C. Lee [Line...

Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk Kaleem Maqsood, Shaaf Ahmad, Azeem Saeed, Nabila Roohi [Line breaks added] Highlights • Plasma fibrinogen and haptoglobin identified as biomarkers for long COVID severity. • Elevated...

Prolonged alterations in red blood cell rheology following mild SARS-CoV-2 infection: Implications for microvascular health Pazara; Tudorache; Dusa; Bjørklund; Dadar; Doşa; Chirumbolo; Cambrea The COVID-19 pandemic has prompted widespread investigation into its systemic effects, focusing on the...

Crosstalk Among Disrupted Blood-Brain Barrier, Neuroinflammation, and Coagulopathy in AC70 hACE2 Tg Mice with Prolonged Neurological Manifestations Induced by the Omicron BA.1 Variant of SARS-CoV-2 Aleksandra K Drelich; Panatda Saenkham-Huntsinger; Yu-Hsiu E. Wang; Xuping Xie; Barbara M. Judy...

Abstract Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection1,2,3,4. Despite the clinical evidence1,5,6,7, the underlying mechanisms of coagulopathy in...

SARS-CoV-2 spike protein potentiates platelet aggregation via upregulating integrin αIIbβ3 outside-in signaling pathway Wang, Ruijie; Tian, Zezhong; Zhu, Meiyan; Zhang, Bingying; Li, Yanzhang; Zheng, Yiqi; Mao, Yuheng; Zhao, Yimin; Yang, Yan Platelet hyperreactivity is one of the crucial causes...

Differential Gene Expression in the Upper Respiratory Tract following Acute COVID-19 Infection in Ambulatory Patients That Develop Long COVID Biondi, Mia J.; Addo, Mary; Zahoor, Muhammad Atif; Salvant, Elsa; Yip, Paul; Barber, Bethany; Smookler, David; Wasif, Sumaiyah; Gaete, Kayla; Kandel...

Extreme γ′ fibrinogen levels in COVID-19 patients Hudkins; Hamilton; Underwood; Kazmierczak; Dewey; Kazmierczak; Messer; Khan; Schreiber; Farrell COVID-19 disease progression can be accompanied by a “cytokine storm” that leads to secondary sequelae such as acute respiratory distress syndrome...

Abstract Background Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inflammation and neurodegeneration post-TBI is not fully understood...

Amyloid-Fibrinogen Aggregates Microclots Predict Risks of Disseminated Intravascular Coagulation and Mortality Schofield, Jeremy; Abrams, Simon Timothy; Jenkins, Rosalind; Lane, Steven; Wang, Guozheng; Toh, Cheng-Hock Microclots have been associated with various conditions, including post-acute...

Published version linked in this later post here Preprint Abstract The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent...

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics Petersen, Mark A.; Ryu, Jae Kyu; Akassoglou, Katerina The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood–brain barrier (BBB)...

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization Abstract Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the...

Exploring microplastic impact on whole blood clotting dynamics utilizing thromboelastography Christodoulides, Alexei; Hall, Abigail; Alves, Nathan J. This study investigates the influence of microplastics on blood clotting. It addresses the lack of comprehensive research on the effects of...

Persistent immune and clotting dysfunction detected in saliva and blood plasma after COVID-19 Hyesun Jang; Saibyasachi Choudhury; Yanbao Yu; Benjamin L. Sievers; Terri Gelbart; Harinder Singh; Stephen A. Rawlings; Amy Proal; Gene S. Tan; Yu Qian; Davey Smith; Marcelo Freire A growing number of...

Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19? Gerencer, Marijan; McGuffin, Liam J. The previous studies on the RGD motif (aa403-405) within the SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that...

COVID-19 patient fibrinogen produces dense clots with altered polymerization kinetics, partially explained by increased sialic acid Moiseiwitsch N, Zwennes N, Szlam F, Sniecinski R, Brown A Background: Thrombogenicity is a known complication of COVID-19, resulting from SARS-Cov-2 infection...

Fibrinogen is a large molecule synthesized in the liver and released in the blood. Circulating levels of fibrinogen are upregulated after bleeding or clotting events and support wound healing. In the context of an injury, thrombin activation drives conversion of fibrinogen to fibrin. Fibrin...

Abstract Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many...

Abstract Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, the mechanisms that link disruption of the blood–brain...