fibrin

Imaging of Thromboinflammation by Multispectral 19F MRI Temme, Sebastian; Kleimann, Patricia; Tiren, Zeynep-Büsra; Bouvain, Pascal; Zielinski, Arthur; Dollmeyer, William; Poth, Sarah; Görges, Juliana; Flögel, Ulrich The close interplay between thrombotic and immunologic processes plays an...

Abstract Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection1,2,3,4. Despite the clinical evidence1,5,6,7, the underlying mechanisms of coagulopathy in...

Abstract Background Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inflammation and neurodegeneration post-TBI is not fully understood...

Persistent hypofibrinolysis in severe COVID-19 associated with elevated fibrinolysis inhibitors activity Okazaki, Erica; Barion, Bárbara Gomes; da Rocha, Tania Rubia Flores; Di Giacomo, Giovanna; Ho, Yeh-Li; Rothschild, Cynthia; Fatobene, Giancarlo; de Carvalho Moraes, Bruna del Guerra...

Tale of two systems: the intertwining duality of fibrinolysis and lipoprotein metabolism Wen Dai; Mark Castleberry; Ze Zheng Fibrinolysis is an enzymatic process that breaks down fibrin clots, while dyslipidemia refers to abnormal levels of lipids and lipoproteins in the blood. Both...

Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis Asim Cengiz Akbulut; Ryanne A. Arisz; Constance C. F. M. J. Baaten; Gaukhar Baidildinova; Aarazo Barakzie; Rupert Bauersachs; Jur ten Berg; Wout W. A. van den Broek; H. C. de Boer; Amandine...

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics Petersen, Mark A.; Ryu, Jae Kyu; Akassoglou, Katerina The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood–brain barrier (BBB)...

Exploring microplastic impact on whole blood clotting dynamics utilizing thromboelastography Christodoulides, Alexei; Hall, Abigail; Alves, Nathan J. This study investigates the influence of microplastics on blood clotting. It addresses the lack of comprehensive research on the effects of...

Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome Inderjit Singh; Brooks P. Leitner; Yiwei Wang; Hanming Zhang; Phillip Joseph; Denyse...

Abstract Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation of individuals with long COVID...

Abstract Background Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) and Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form a suitable set of foci for the clinical...

Fibrinogen is a large molecule synthesized in the liver and released in the blood. Circulating levels of fibrinogen are upregulated after bleeding or clotting events and support wound healing. In the context of an injury, thrombin activation drives conversion of fibrinogen to fibrin. Fibrin...

Abstract Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many...

Abstract Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, the mechanisms that link disruption of the blood–brain...

Amyloidogenesis of SARS-CoV-2 Spike Protein Sofie Nyström, Per Hammarström Abstract SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and...

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy (Non peer-reviewed) Jae Kyu Ryu, Elif G Sozmen, Karuna Dixit, Mauricio Montano, Yusuke Matsui, Yixin Liu, Ekram Helmy, Thomas J Deerinck, Zhaoqi Yan, Renaud Schuck, Rosa Meza Acevedo, Collin M...

A macrophage attack culminating in microthromboses characterizes COVID 19 pneumonia Brian S Bull, Karen L Hay Introduction: A neutrophilic infiltrate characterizes bacterial pneumonia. Macrophage infiltration is similarly characteristic of the viral pneumonia caused by SARS-CoV-2. These...

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics Etheresia Pretorius, Janette Bester, Natasha Vermeulen, Sajee Alummoottil, Prashilla Soma, Antoinette V...

Fibrinogen Glycation and Presence of Glucose Impair Fibrin Polymerization—An In Vitro Study of Isolated Fibrinogen and Plasma from Patients with Diabetes Mellitus Boguslawa Luzak, Magdalena Boncler, Marcin Kosmalski, Ewelina Mnich, Lidia Stanczyk, Tomasz Przygodzki and Cezary Watala Abstract...

Glucose Concentration Affects Fibrin Clot Structure and Morphology as Evidenced by Fluorescence Imaging and Molecular Simulations Jacob E. Hood, Sumith Yesudasan and Rodney D. Averett Abstract Although in vivo studies have been conducted in the past to determine hyperglycemic effects and...