Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19
Jiangfeng Liu; Li Guo; Jingchuan Zhong; Yue Wu; Xinming Wang; Xiaoyue Tang; Kaiyuan Min; Yehong Yang; Wanjun Peng; Qiaochu Wang; Tao Ding; Xiaoying...
CspZ variant–specific interaction with factor H incorporates a metal site to support Lyme borreliae complement evasion
Kalvis Brangulis; Valerie Sürth; Ashley L. Marcinkiewicz; Inara Akopjana; Andris Kazaks; Janis Bogans; Alisa Huber; Yi-Pin Lin; Peter Kraiczy
Polymorphic microbial immune...
2015 study
Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome
Mangalathu S. Rajeevan, Irina Dimulescu, Janna Murray 1, Virginia R. Falkenberg, Elizabeth R. Unger
Abstract
Recent evidence suggests immune and inflammatory alterations are...
Abstract:
The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been...
ABSTRACT
The complement system is a vital anti-microbial defence mechanism against circulating pathogens. Excessive complement activation can have deleterious outcomes for the host and is consequently tightly modulated by a set of membrane-associated and fluid-phase regulators of complement...
Abstract
Myalgic Encephalomyelitis (ME; sometimes referred to as chronic fatigue syndrome) is a relatively common and female-biased disease of unknown pathogenesis that profoundly decreases patients' health-related quality-of-life. ME diagnosis is hindered by the absence of robustly-defined and...
Published abstract and link here
Preprint
Complement dysregulation is a predictive and therapeutically amenable feature of long COVID
Background: Long COVID encompasses a heterogeneous set of ongoing symptoms that affect many individuals after recovery from infection with severe acute...
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