extracellular vesicles

Preprint. Now published - see post #18 This is from Maureen Hanson's group. Abstract In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue, and reduces risk of chronic diseases. Although exercise is suggested as a lifestyle...

Newly uncovered biochemical and functional aspects of ferritin Izumi Yanatori; Sohji Nishina; Fumio Kishi; Keisuke Hino Iron homeostasis is strictly regulated at both the systemic and cellular levels by complex mechanisms because of its indispensability and toxicity. Among the various...

Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function Molly S. George; Jenifer Sanchez; Christina Rollings; David Fear; Peter Irving; Linda V. Sinclair; Anna Schurich Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T...

Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms Diana Romenskaja; Ugne Jonavice; Augustas Pivoriunas Autophagy dysfunction has been closely related with pathogenesis of many neurodegenerative diseases and therefore represents a potential...

Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, heterogenous disease characterized by unexplained persistent fatigue and other features including cognitive impairment, myalgias, post-exertional malaise, and immune system dysfunction. Cytokines are present in...

Abstract Pericytes (PCs), as a central component of the neurovascular unit, contribute to the regenerative potential of the central nervous system (CNS) and peripheral nervous system (PNS) by virtue of their role in blood flow regulation, angiogenesis, maintenance of the BBB, neurogenesis, and...

Abstract Although a number of studies have demonstrated increased release of extracellular vesicles (EVs) and changes in their origin differentials after trauma, the biologic significance of EVs is not well understood. We hypothesized that EVs released after trauma/hemorrhagic shock (HS)...

Persistent Presence of Spike protein and Viral RNA in the Circulation of Individuals with Post-Acute Sequelae of COVID-19 Vaughn Craddock, Aatish Mahajan, Balaji Krishnamachary, Leslie Spikes, PrabhakarChalise, Navneet Kaur Dhillon SARS-CoV-2, the causative agent of COVID-19 disease has...

Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study Johanna Wallensten, Fariborz Mobarrez, Marie Åsberg, Kristian Borg, Aniella Beser, Alexander Wilczek & Anna Nager "Abstract Vascular endothelial growth factor (VEGF) has been...

Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study Johanna Wallensten, Anna Nager, Marie Åsberg, Kristian Borg, Aniella Beser, Alexander Wilczek & Fariborz Mobarrez "Abstract Patients with stress-induced exhaustion disorder (SED)...

Full title: Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome With Partial Least Squares Discriminant Analysis: Relevance of Blood Extracellular Vesicles Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic disease characterized by long-lasting persistent...

https://www.frontiersin.org/articles/10.3389/fimmu.2022.841910/full Myalgic encephalomyelitis, or chronic fatigue syndrome (ME/CFS) is a serious disease whose cause has yet to be identified. Objective markers of the disease are also not well understood and would serve as important tools in...

Highlights • Mitochondrial stress stimulates adipocyte sEV release • Adipocyte stress-induced sEVs are enriched with oxidatively damaged mitochondria • Mitochondria in sEVs from stressed adipocytes induce a burst of ROS in cardiac tissue • The adipocyte-derived pro-oxidant signal protects...

Neutrophil Extracellular Traps (NETs) are potentially of interest to us. This image from a 2020 paper by a Chinese team (Neutrophil Extracellular Traps: Signaling Properties and Disease Relevance Tiewei Li, Zhengyan Zhang, Xiaojuan Li, Geng Dong, Min Zhang, Zhe Xu, and Junmei Yang) gives a feel...

Mini Review ARTICLE Marta Lombardi1, Martina Gabrielli1, Elena Adinolfi2 and Claudia Verderio1* 1CNR Institute of Neuroscience, Research Labs–University Milano-Bicocca, Vedano al Lambro, Italy 2Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara...

https://www.mdpi.com/2073-4409/10/2/386 Abstract As the SARS-CoV-2 pandemic continues, reports have demonstrated neurologic sequelae following COVID-19 recovery. Mechanisms to explain long-term neurological sequelae are unknown and need to be identified. Plasma from 24 individuals recovering...

Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study Ludovic Giloteaux, Adam O'Neal, Jesús Castro-Marrero, Susan M. Levine & Maureen R. Hanson Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)...

Full Title: Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome https://www.nature.com/articles/s41598-020-58506-5

Cargo-Loading of Misfolded Proteins into Extracellular Vesicles: The Role of J Proteins https://www.biorxiv.org/content/10.1101/310219v2 http://microvesicles.org/index.html https://www.exosome-rna.com/vesiclepedia-2019-a-compendium-of-rna-proteins-lipids-and-metabolites-in-extracellular-vesicles/

Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/ chronic fatigue syndrome AkikoEguchi,SanaeFukuda,HirohikoKuratsunede,JunzoNojimag,YasuhitoNakatomi,YasuyoshiWatanabee,Ariel E.Feldstein...