extracellular vesicles

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation [Line breaks added] Background: Subjects with Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC)...

Increased mannosylation of extracellular vesicles in Long COVID plasma provides a potential therapeutic target for Galanthus nivalis agglutinin GNA affinity resin There is no proven therapy for Long COVID, a post-acute illness characterized by a myriad of diverse symptoms including fatigue...

Erythrocytes as a Source of Exerkines Exercise activates many metabolic and signaling pathways in skeletal muscle and other tissues and cells, causing numerous systemic beneficial metabolic effects. Traditionally recognized for their principal role in oxygen (O2) transport, erythrocytes have...

A Guide for Studying Mitochondria Transfer Tiash S, Brestoff JR, Crewe C. Abstract Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering circulation. Here, we briefly review the state of the mitochondria transfer field...

Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis Ji T, Zhao T, Long S, Wei C, Cheng D, Chen J, Kuang L Abstract The inflammatory cytokine storm is a hallmark of sepsis and is highly correlated with organ injury. Therefore, inhibiting...

Mechanisms of resistance to daratumumab in patients with multiple myeloma Iversen KF Abstract Multiple myeloma (MM) is an incurable cancer in the bone marrow. The treatment of MM has developed significantly during the last 20 years, which has resulted in increased survival. Daratumumab is the...

Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia Fang; Zhang; Xu; Wang; He; Liao; Yuan; Tang Schizophrenia is a severe and clinically heterogeneous mental disorder, with approximately 30 % of patients developing treatment resistance to standard...

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers Lei Wang, Yujia Xu, Xiang Zhong, Guiping Wang, Zijun Shi, Can Mei, Linwanyue Chen, Jianbo Zhan, Jing Cheng [Line breaks added] Abstract Chronic fatigue syndrome (CFS) is a...

Possible long COVID biomarker: identification of SARC-CoV-2 related protein(s) in Serum Extracellular Vesicles Asghar Abbasi, Ritin Sharma, Nathaniel Hansen, Patrick Pirrotte & William W. Stringer [Snippets from correspondence with no abstract, bolding added] Web | PDF | Infection | Open...

Annexin–Membrane Interactions Across Eukaryotic Domains of Life—A Comparative Approach Warmus, Dawid; Balmer, Erina Alexandra; Faso, Carmen This review explores the interaction of annexins with membranes across a variety of eukaryotic domains of life, highlighting this protein family’s role in...

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson [Line...

Proteomic profiling of serum small extracellular vesicles predicts post-COVID syndrome development Dobra; Gyukity-Sebestyen; Bukva; Boroczky; Nyiraty; Bordacs; Varkonyi; Kocsis; Szabo; Kecskemeti; Polgar; Szell; Buzas Post-COVID syndrome affects 10–35 % of COVID-19 patients, and up to 85 % of...

Sympathetic Neural Overdrive, Vascular Dysfunction and Diminished Exercise Capacity in Long COVID-19 Patients: A Long-Term Study of Cardiovascular Sequelae Bruna E. Ono; João E. Izaias; Artur O. Sales; Thais S. Rodrigues; Camila S. Nunes; Jessica F. Niec; Natalia G. Rocha; Helena N.M. Rocha...

Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity Yuzhou Zeng; Anna Antoniou Mitochondrial metabolism in neurons is necessary for energetically costly processes like synaptic transmission and plasticity. As...

MicroRNA Profiling of Blood Extracellular Vesicles in ME/CFS Ljungström, María; Nathanson, Lubov; Oltra, Elisa Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating neuroimmune disease affecting many organs and systems which, in the absence of validated...

SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles Sara Bachiller, Joana Vitalle, Lluís Camprubí-Ferrer, Manuel García, Isabel Gallego, Marina López-García, María Isabel Galvá, Julio Cañizares, Inmaculada Rivas-Jeremías, María Díaz-Mateos, Carmen Gasca-Capote...

Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response Arpita Balakrishnan, Gabriela Winiarek, Olga Ho, Jakub Godlewski, Agnieszka Bronisz Abstract The immunopeptidome, a diverse set of peptides presented by Major Histocompatibility...

Surface Protein Profiling of Extracellular Vesicles: A Novel Biomarker Approach for Long COVID Diagnosis? Gentaro Ikeda, Prasanna Jagannathan, Mario Leki, Hiroyuki Inoue, Vanessa El Kamari, Arya V Dadhania, Mitchell Miglis, Robert W Shafer, Linda N Geng, Phillip C Yang, Hector F Bonilla...

Platelets as key cells in endometriosis patients: Insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis Barbara Bortot; Roberta Di Florio; Simona Merighi; Ben Peacock; Rebecca Lees; Francesco Valle; Marco Brucale; Alessandro Mangogna; Giovanni Di...