deconditioning

Abstract: Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance...

Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition – a randomized controlled trial Barz, Andreas; Berger, Joshua; Speicher, Marco; Morsch, Arne; Wanjek, Markus; Rissland, Jürgen; Jäger, Johannes Fatigue is the most prevalent symptom...

Daily blood flow restriction does not affect muscle fiber capillarization and satellite cell content during two weeks of bed rest in healthy young men Thorben Aussieker; Cas J. Fuchs; Antoine Zorenc; Lex B. Verdijk; Luc J.C. van Loon; Tim Snijders The present study assessed whether single-leg...

Abstract Myalgic Encephalomyelitis (ME; sometimes referred to as chronic fatigue syndrome) is a relatively common and female-biased disease of unknown pathogenesis that profoundly decreases patients' health-related quality-of-life. ME diagnosis is hindered by the absence of robustly-defined and...

Just wrote a blog about what deconditioning looks like and how it differs from ME/CFS. https://mecfsskeptic.com/what-does-deconditioning-look-like/ Interestingly the best evidence on deconditioning comes from NASA bed rest studies. Head-down bed rest was used as a proxy for the low gravity...

Disuse-Induced Muscle Fatigue: Facts and Assumptions Sergeeva, Xenia V.; Lvova, Irina D.; Sharlo, Kristina A. Skeletal muscle unloading occurs during a wide range of conditions, from space flight to bed rest. The unloaded muscle undergoes negative functional changes, which include increased...

Developing effective strategies to optimize physical activity and cardiorespiratory fitness in the long Covid population- The need for caution and objective assessment Faghy; Duncan; Hume; Gough; Roscoe; Laddu; Arena; Asthon; Dalton The Post Covid-19 Condition (commonly known as Long Covid) has...

The Acute, Short-, and Long-Term Effects of Endurance Exercise on Skeletal Muscle Transcriptome Profiles Beiter, Thomas; Zügel, Martina; Hudemann, Jens; Schild, Marius; Fragasso, Annunziata; Burgstahler, Christof; Krüger, Karsten; Mooren, Frank C.; Steinacker, Jürgen M.; Nieß, Andreas M. A...

Dysautonomia, but Not Cardiac Dysfunction, Is Common in a Cohort of Individuals with Long COVID Tabacof, Laura; Wood, Jamie; Breyman, Erica; Tosto-Mancuso, Jenna; Kelly, Amanda; Wilkey, Kaitlyn; Zhang, Chi; Putrino, David; Kontorovich, Amy Despite the prevalence of dysautonomia in people with...

People With Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Exhibit Similarly Impaired Vascular Function Background This study aimed to compare flow-mediated dilation values between individuals with Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome...

Metabolomic Signatures of Sedentary Behavior and Cardiometabolic Traits in US Hispanics/Latinos: Results from HCHS/SOL Moon, Jee-Young;Chai, Jin Choul;Yu, Bing;Song, Rebecca J.;Chen, Guo-Chong;Graff, Mariaelisa;Daviglus, Martha L.;Chan, Queenie;Thyagarajan, Bharat;Castaneda, Sheila F.;Grove...

Post-Acute Sequelae of SARS-CoV-2: More Than Deconditioning Phillip Joseph; Inderjit Singh No abstract. Link | PDF (CHEST)

The Dallas Bed Rest and Training Study Jere H. Mitchell; Benjamin D. Levine; Darren K. McGuire No Abstract. (Summarises findings from the following papers.) Link | PDF (Circulation)

Cardiovascular deconditioning produced by 20 hours of bedrest with head-down tilt −5° in middle-aged healthy men Gaffney; Nixon; Karlsson; Campbell; Dowdey; Blomqvist Cardiovascular deconditioning after prolonged bedrest has been attributed to inactivity. To examine the role of the altered...

Characteristics and Treatment of Exercise Intolerance in Patients With Long COVID Edward, Justin A.;Peruri, Adithya;Rudofker, Eric;Shamapant, Nikhil;Parker, Hugh;Cotter, Ryan;Sabin, Katherine;Lawley, Justin;Cornwell, William K. III The post-acute sequalae of SARS-CoV-2, also known as “Long...

I used to read full papers voraciously and wrote over 100 e-letters along with getting some letters published. Following a discussion about risk factors for CFS today, I was reminded of the following in response to some spin in a paper by Peter White et al. =========...

Abstract Purpose: Previous studies in chronic fatigue syndrome (CFS) have reported reductions in maximal oxygen uptake (VO(2max)), yet often the testing procedures have not followed accepted guidelines, and gender data have been pooled. The present study was undertaken to reevaluate exercise...

Background: Orthostatic intolerance (OI) is a core finding in individuals with myalgic encephalomyelitis /chronic fatigue syndrome (ME/CFS). Deconditioning is often proposed as an important determinant for OI. Deconditioning can be objectively classified using the predicted peak oxygen...

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling Gallo, C., Ridolfi, L. & Scarsoglio, S. Abstract Human spaceflight has been fascinating man for centuries, representing the intangible need to explore the unknown, challenge new frontiers, advance technology...

This public thread is for general discussion of the much anticipated NICE 2021 ME/CFS Guideline including media and social media responses and other organisations' press releases. The NICE ME/CFS Guideline Project documents page gives links to: the Final Guideline the Evidence Review the...