cortisol

Reproducibility of the circadian rhythms of serum cortisol and melatonin in healthy subjects: a study of three different 24-h cycles over six weeks Selmaoui, Brahim; Touitou, Yvan Abstract Plasma melatonin and cortisol are characterized by a marked circadian rhythm, but little information is...

Evidence for Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndrome Abstract Chronic fatigue syndrome is characterized by persistent or relapsing debilitating fatigue for at least 6 months in the absence of a medical diagnosis that would...

Making a thread to start collecting some of the CRH ideas floating around. Everyone free to add anything that seems relevant. Note there is also jnmaciuch's Peripheral neurons, CRH, and sickness behavior thread, which is a bit more focused. I'll probably come back and clean up this first post...

This table is based off the Cortisol levels in ME/CFS thread. I have been picking away at this over the past couple days (I am skimming each paper as well as Hutan's great notes, so going is slow). I figured it would be good to share the tiny bit I've done so far in case anyone has important...

Neuroendocrine signature of ME/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a major clinical challenge as a complex multisystemic disorder with no well-established...

The cyclic alternating pattern demonstrates increased sleep instability and correlates with fatigue and sleepiness in adults with upper airway resistance syndrome Christian Guilleminault, M Cecilia Lopes, Chad C Hagen, Agostinho da Rosa...

The role of hypocortisolism in chronic fatigue syndrome Abstract Abstract Background: There is accumulating evidence of hypothalamic-pituitary-adrenal (HPA) axis hypofunction in chronic fatigue syndrome (CFS). However, knowledge of this hypofunction has so far come exclusively from research...

https://www.tandfonline.com/doi/full/10.1080/10253890.2026.2638303 Research Article The association between hair cortisol levels, Epstein-Barr virus infections and chronic fatigue in adolescents Berit Elise Bergem Kongsnes , Tarjei Tørre Asprusten , Vegard Bruun Bratholm Wyller & Maria...

Spironolactone for ME/CFS in a Patient Homozygous for rs5522 (I180V): A Case Report Donnellan, Patricia Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition with no consistently effective treatment. The mineralocorticoid receptor variant...

2001 paper Several neuroendocrine studies have suggested hypoactivation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome. One possible determinant of this neuroendocrine abnormality, as well as the primary symptom of fatigue, is reduced hypothalamic secretion of...

Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome Peter Novak; David M Systrom; Alexandra Witte; Sadie P Marciano; Donna Felsenstein; Jeff M Milunsky; Aubrey Milunsky; Joel Krier; Mark C Fishman INTRODUCTION Long COVID and myalgic...

Salivary cortisol in long COVID: a marker of broader stress system and circadian rhythm dysregulation INTRODUCTION Long COVID (LC) has been associated with hypothalamic–pituitary–adrenal (HPA) axis dysfunction, although findings from blood cortisol measurements remain inconsistent. We...

Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone Long COVID (LC) may involve endocrine dysfunction; however, the underlying mechanism remains unclear. To examine hypothalamic–pituitary responses in...

A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystem illnesses with overlapping symptoms and poorly understood...

Hormonal alterations in adolescent chronic fatigue syndrome Aim The chronic fatigue syndrome is associated with alterations in the hypothalamus‐pituitary‐adrenal axis and cardiovascular autonomic nervous activity, suggesting a central dysregulation. This study explored differences among...

https://www.healthrising.org/blog/2025/12/04/chronic-fatigue-hpa-axis-autopsy/ All in all, the HPA axis with the dramatic reduction of CRH-producing neurons in the hypothalamus, a shutdown of the pituitary, and lower cortisol levels found appeared to be pretty much of a wreck in these...

Can Low Cortisol Predict Long COVID? A Controversial Issue Cortisol dysregulation has been proposed as a biomarker of long COVID (LC), but findings remain inconsistent. Prior reports suggested low cortisol levels in LC, yet collection times and study designs varied substantially. To evaluate...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1 Highlights • Female long COVID (LC) patients show heightened immune activation and inflammation • Disrupted sex hormone levels differ between male and female LC patients • Neuroinflammatory gene signatures may explain...

The potential bidirectional relationship between long COVID and menstruation Women have reported menstrual changes following SARS-CoV-2 infection and variation in long COVID symptoms across the menstrual cycle. We examined (i) whether COVID is linked to abnormal uterine bleeding (AUB), (ii) if...

Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry Natalie Thomas, S. J. Kumari A. Ubhayasekera, Christopher W. Armstrong, Katherine Huang, Jonas Bergquist [Line...