clinical trial

https://www.simmaronresearch.com/rapamycin-trial The First Biomarker-Driven Treatment Trial for ME/CFS Subsets Mean Success Until now, the heterogeneity of the patient population and the lack of a reliable biomarker to diagnose and prognose ME/CFS has thwarted clinical trials for both...

(Reuters) - Tonix Pharmaceuticals Holding Corp said on Tuesday its experimental drug failed to meet the primary goal in a mid-stage study for management of widespread muscle pain and tenderness associated with long COVID-19. Shares of the company were down 12% in premarket trading. The...

http://www.geneuro.com/fr/patients-fr/francais The GNC-501 study, titled “Temelimab as a Disease Modifying Therapy in Patients with Neurological, Neuropsychological, and Psychiatric Symptoms in Post-COVID-19 or Post-Acute Sequelae of COVID-19 (PASC) Syndrome,” will enroll 200 patients from...

A chilling account by Robert Cockburn, an Australian journalist, of how he was harmed by unapproved experimental devices in an asthma trial at Sydney University’s Woolcock Institute of Medical Research. He sustained long-term respiratory and neurological injuries from one of the devices. When...

I found this from twitter, with an excellent thread here: It is a negative study from 4 arms clinical trial. The results have been rendered somewhat more positive than what they are as explained in the twitter thread and in the conclusion of the paper Here is the abstract: Abstract...

Completeness of clinical evidence citation in trial protocols: A cross-sectional analysis, Cell Med, Sheng, Feldhake, Zarin, Kimmelman, 2022. Summary Background Human protection policies require assessment of how proposed clinical trials relate to prior and ongoing studies testing similar...

Table with short overview at the bottom of the link. https://www.clinicaltrialsarena.com/analysis/long-covid-19-drug-trial-results-to-watch-in-2022/

Study has been approved by the South African Health Authority for individuals with documented COVID-19 infections who develop debilitating physical and neuropsychiatric symptoms that persist for more than 12 weeks after the viral infection has passed - Enrollment is expected to commence in Q1...

Recruitment characteristics and non-adherence associated factors of fibromyalgia patients in a randomized clinical trial: A retrospective survival analysis Abstract Introduction Fibromyalgia is a complex pain condition that affects mostly women. Given the disease's lack of understanding...

Full title: Comparison of a Single-Session Pain Management Skills Intervention With a Single-Session Health Education Intervention and 8 Sessions of Cognitive Behavioral Therapy in Adults With Chronic Low Back Pain, A Randomized Clinical Trial Question Is a single-session pain relief class...

There is a thread that tries to collect adequately controlled clinical trials and reviews on therapist-delivered/ non-drug interventions for illnesses and symptoms that don't have biomarkers yet here. Thought it could be also helpful to have a meta-thread collecting both well done and badly...

Post-acute COVID-19 syndrome (PACS) is a collection of persistent and debilitating symptoms lasting weeks to months after acute COVID-19 infection, with fatigue most commonly reported. There is controversy surrounding the role of exercise programs for this condition, due to concerns over the...

Abstract The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy. L‐kynurenine (LKYN), the first active metabolite in the pathway, emerges to be a prodrug...

Full title: The ME-SH (Myalgic Encephalomyelitis in Stockholm-Harvard) Study: Structural Problems in Brainstem and Cervical Spine Cord in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome(ME/CFS) - a Case-control Study Not yet recruiting...

Full title: Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial. Athinarayanan et al. Front Endocrinol (2019)

From the trial data https://clinicaltrials.gov/ct2/show/NCT03677206 From an article in Pain New: https://www.painnewsnetwork.org/stories/2020/11/10/pilot-study-finds-green-light-therapy-improves-fibromyalgia-symptoms There is rat data, but on human "blinding" of green light vs. white light, it...

An SSRI to treat early COVID, supposedly SSRIs can inhibit SARS-CoV-2 and also potentially have anti-inflammatory and immunoregulatory properties. I think also earlier this year there was an observational study showing patients taking SSRIs had lower risk of severe COVID and death (I think a...

Abstract: Background Postural orthostatic tachycardia syndrome (POTS) is an autonomic nervous system disorder causing an abnormal cardiovascular response to upright posture. It affects around 0.2% of the population, most commonly women aged 13 to 50 years. POTS can be debilitating...

Evelien and I were interested in what clinical trials are currently planned or ongoing for ME/CFS. It can take many years to conduct a clinical trial and report the results, so we wanted to know what we can expect to come out in the next years. A search of databases that register clinical...

From their May Momentum 2020 newsletter & https://www.omf.ngo/maymomentum/ Post-COVID19 study: https://www.omf.ngo/2020/04/26/tracking-covid-19-patients/ Mestinon trial: https://www.omf.ngo/2020/04/26/the-mestinon-clinical-trial-for-me-cfs/ &...